Origin and Evolution of Poxviruses

John W. Barrett; Grant McFadden

doi:10.1016/B978-0-12-374153-0.00019-9

Origin and Evolution of Poxviruses

John W. Barrett, Grant McFadden

Research output: Chapter in Book/Report/Conference proceeding › Chapter

19 Scopus citations

Abstract

The family Poxviridae is a large and diverse family of double-stranded DNA viruses with ubiquitous distribution. Poxviruses parasitize invertebrates, birds, reptiles and mammals suggesting that the family Poxviridae is an ancient virus family. The genomes are linear and encode a large complement of genes. Essential viral functions are clustered in the central region of the genome and a core group of critical genes are conserved among all poxviruses. In contrast, species-specific genes, necessary for host infection and virus virulence, are maintained near the termini. The success of the poxvirus family members is based on the acquisition of cellular genes that have evolved under viral/host selection to permit the virus to modulate the host immune response.

Original language	English (US)
Title of host publication	Origin and Evolution of Viruses, Second Edition
Publisher	Elsevier
Pages	431-446
Number of pages	16
ISBN (Electronic)	9780123741530
DOIs	https://doi.org/10.1016/B978-0-12-374153-0.00019-9
State	Published - Jan 1 2008
Externally published	Yes

ASJC Scopus subject areas

Immunology and Microbiology(all)

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10.1016/B978-0-12-374153-0.00019-9

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abstract = "The family Poxviridae is a large and diverse family of double-stranded DNA viruses with ubiquitous distribution. Poxviruses parasitize invertebrates, birds, reptiles and mammals suggesting that the family Poxviridae is an ancient virus family. The genomes are linear and encode a large complement of genes. Essential viral functions are clustered in the central region of the genome and a core group of critical genes are conserved among all poxviruses. In contrast, species-specific genes, necessary for host infection and virus virulence, are maintained near the termini. The success of the poxvirus family members is based on the acquisition of cellular genes that have evolved under viral/host selection to permit the virus to modulate the host immune response.",

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AB - The family Poxviridae is a large and diverse family of double-stranded DNA viruses with ubiquitous distribution. Poxviruses parasitize invertebrates, birds, reptiles and mammals suggesting that the family Poxviridae is an ancient virus family. The genomes are linear and encode a large complement of genes. Essential viral functions are clustered in the central region of the genome and a core group of critical genes are conserved among all poxviruses. In contrast, species-specific genes, necessary for host infection and virus virulence, are maintained near the termini. The success of the poxvirus family members is based on the acquisition of cellular genes that have evolved under viral/host selection to permit the virus to modulate the host immune response.

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Origin and Evolution of Poxviruses

Abstract

ASJC Scopus subject areas

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