Origin and Evolution of Poxviruses

John W. Barrett; Douglas McFadden

doi:10.1016/B978-0-12-374153-0.00019-9

Origin and Evolution of Poxviruses

John W. Barrett, Douglas McFadden

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

The family Poxviridae is a large and diverse family of double-stranded DNA viruses with ubiquitous distribution. Poxviruses parasit-ize invertebrates, birds, reptiles and mam-mals suggesting that the family Poxviridae is an ancient virus family. The genomes are lin-ear and encode a large complement of genes. Essential viral functions are clustered in the central region of the genome and a core group of critical genes are conserved among all pox-viruses. In contrast, species-specific genes, nec-essary for host infection and virus virulence, are maintained near the termini. The success of the poxvirus family members is based on the acquisition of cellular genes that have evolved under viral/host selection to permit the virus to modulate the host immune response.

Original language	English (US)
Title of host publication	Origin and Evolution of Viruses
Publisher	Elsevier Ltd
Pages	431-446
Number of pages	16
ISBN (Print)	9780123741530
DOIs	https://doi.org/10.1016/B978-0-12-374153-0.00019-9
State	Published - Dec 1 2008
Externally published	Yes

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ASJC Scopus subject areas

Immunology and Microbiology(all)

Cite this

Barrett, J. W., & McFadden, D. (2008). Origin and Evolution of Poxviruses. In Origin and Evolution of Viruses (pp. 431-446). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-374153-0.00019-9

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Access to Document

10.1016/B978-0-12-374153-0.00019-9