Oriented collagen fibers direct tumor cell intravasation

Weijing Han, Shaohua Chen, Wei Yuan, Qihui Fan, Jianxiang Tian, Xiaochen Wang, Longqing Chen, Xixiang Zhang, Weili Wei, Ruchuan Liu, Junle Qu, Yang Jiao, Robert H. Austin, Liyu Liu

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Original languageEnglish (US)
Pages (from-to)11208-11213
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number40
DOIs
StatePublished - Oct 4 2016

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Keywords

  • Cancer
  • Collagen
  • Intravasation
  • Microenvironment
  • Oriented invasion

ASJC Scopus subject areas

  • General

Cite this

Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H., & Liu, L. (2016). Oriented collagen fibers direct tumor cell intravasation. Proceedings of the National Academy of Sciences of the United States of America, 113(40), 11208-11213. https://doi.org/10.1073/pnas.1610347113