Oriented collagen fibers direct tumor cell intravasation

Weijing Han; Shaohua Chen; Wei Yuan; Qihui Fan; Jianxiang Tian; Xiaochen Wang; Longqing Chen; Xixiang Zhang; Weili Wei; Ruchuan Liu; Junle Qu; Yang Jiao; Robert H. Austin; Liyu Liu

doi:10.1073/pnas.1610347113

Oriented collagen fibers direct tumor cell intravasation

Weijing Han, Shaohua Chen, Wei Yuan, Qihui Fan, Jianxiang Tian, Xiaochen Wang, Longqing Chen, Xixiang Zhang, Weili Wei, Ruchuan Liu, Junle Qu, Yang Jiao, Robert H. Austin, Liyu Liu

Research output: Contribution to journal › Article › peer-review

238 Scopus citations

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Original language	English (US)
Pages (from-to)	11208-11213
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	40
DOIs	https://doi.org/10.1073/pnas.1610347113
State	Published - Oct 4 2016

Keywords

Cancer
Collagen
Intravasation
Microenvironment
Oriented invasion

ASJC Scopus subject areas

General

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10.1073/pnas.1610347113

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title = "Oriented collagen fibers direct tumor cell intravasation",

abstract = "In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).",

keywords = "Cancer, Collagen, Intravasation, Microenvironment, Oriented invasion",

author = "Weijing Han and Shaohua Chen and Wei Yuan and Qihui Fan and Jianxiang Tian and Xiaochen Wang and Longqing Chen and Xixiang Zhang and Weili Wei and Ruchuan Liu and Junle Qu and Yang Jiao and Austin, {Robert H.} and Liyu Liu",

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doi = "10.1073/pnas.1610347113",

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TY - JOUR

T1 - Oriented collagen fibers direct tumor cell intravasation

AU - Han, Weijing

AU - Chen, Shaohua

AU - Yuan, Wei

AU - Fan, Qihui

AU - Tian, Jianxiang

AU - Wang, Xiaochen

AU - Chen, Longqing

AU - Zhang, Xixiang

AU - Wei, Weili

AU - Liu, Ruchuan

AU - Qu, Junle

AU - Jiao, Yang

AU - Austin, Robert H.

AU - Liu, Liyu

PY - 2016/10/4

Y1 - 2016/10/4

N2 - In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

AB - In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

KW - Cancer

KW - Collagen

KW - Intravasation

KW - Microenvironment

KW - Oriented invasion

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U2 - 10.1073/pnas.1610347113

DO - 10.1073/pnas.1610347113

M3 - Article

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AN - SCOPUS:84989874792

SN - 0027-8424

VL - 113

SP - 11208

EP - 11213

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 40

ER -

Oriented collagen fibers direct tumor cell intravasation

Abstract

Keywords

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