Organization of Two Genes Encoding Cytotoxic T Lymphocyte-Specific Serine Proteases CCPI and CCPII

Corrinne G. Lobe, Chris Upton, Brenda Duggan, Nancy Ehrman, Marc Letellier, John Bell, Grant McFadden, R. Chris Bleackley

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The genes encoding two recently described cytotoxic T cell proteases, CCPI and CCPII, have been isolated and sequenced. The organizations of the coding and noncoding portions of the two genes are very similar to each other and also to the gene encoding rat mast cell protease type II. Similarly to other serine protease genes, each of the active-site residues is contained on a separate exon; however, two introns were found in particularly interesting positions. One occurs within the postulated activation dipeptide and the other in a position close to the active-site Asp residue. This latter intron interrupts the amino acid sequence in the invariant core region of the protein. We believe that these genes represent a new subfamily of serine protease genes.

Original languageEnglish (US)
Pages (from-to)6941-6946
Number of pages6
JournalBiochemistry
Volume27
Issue number18
DOIs
StatePublished - Sep 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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