Oral Human Papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners

Gypsyamber D'Souza, Neil D. Gross, Sara I. Pai, Robert Haddad, Karen Anderson, Shirani Rajan, Jennifer Gerber, Maura L. Gillison, Marshall R. Posner

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Purpose: To better understand oral human papillomavirus (HPV) infection and cancer risk among long-term sexual partners of patients with HPV-positive oropharyngeal cancer (HPV-OPC). Patients and Methods: An oral rinse sample, risk factor survey, cancer history, and oral examination (partners only) were collected from patients with HPV-OPC and their partners. Oral rinse samples were evaluated for 36 types of HPV DNA using PGMY 09/11 primers and line-blot hybridization and HPV16 copy number using quantitative polymerase chain reaction. Oral HPV prevalence was compared with infection among those age 45 to 65 years using National Health and Nutrition Examination Survey (NHANES) 2009-2010. Results: A total of 164 patients with HPV-OPC and 93 of their partners were enrolled. Patients were primarily men (90%), were never-smokers (51%), and had performed oral sex (97%), with a median age of 56 years; they had a high prevalence of oncogenic oral HPV DNA (61%) and oral HPV16 DNA (54%) at enrollment. Female partners had comparable oncogenic oral HPV prevalence compared with members of the general population of the same age (1.2% v 1.3%). Among the six male partners, no oncogenic oral HPV infections were detected. No precancers or cancers were identified during partner oral cancer screening examinations. However, a history of cervical disease was reported by nine partners (10.3%) and two female patients (11.8%), and three patients (2.0%) reported a previous partner who developed invasive cervical cancer. Conclusion: Oral HPV16 DNA is commonly detected among patients with HPV-OPC at diagnosis, but not among their partners. Partners of patients with HPV-OPC do not seem to have elevated oral HPV infection compared with the general population.

Original languageEnglish (US)
Pages (from-to)2408-2415
Number of pages8
JournalJournal of Clinical Oncology
Volume32
Issue number23
DOIs
StatePublished - Aug 10 2014

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Oropharyngeal Neoplasms
Papillomavirus Infections
Mouth Neoplasms
DNA
Oral Diagnosis
Nutrition Surveys
Sexual Partners
Early Detection of Cancer
Uterine Cervical Neoplasms
Sexual Behavior
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Oral Human Papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. / D'Souza, Gypsyamber; Gross, Neil D.; Pai, Sara I.; Haddad, Robert; Anderson, Karen; Rajan, Shirani; Gerber, Jennifer; Gillison, Maura L.; Posner, Marshall R.

In: Journal of Clinical Oncology, Vol. 32, No. 23, 10.08.2014, p. 2408-2415.

Research output: Contribution to journalArticle

D'Souza, G, Gross, ND, Pai, SI, Haddad, R, Anderson, K, Rajan, S, Gerber, J, Gillison, ML & Posner, MR 2014, 'Oral Human Papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners', Journal of Clinical Oncology, vol. 32, no. 23, pp. 2408-2415. https://doi.org/10.1200/JCO.2014.55.1341
D'Souza, Gypsyamber ; Gross, Neil D. ; Pai, Sara I. ; Haddad, Robert ; Anderson, Karen ; Rajan, Shirani ; Gerber, Jennifer ; Gillison, Maura L. ; Posner, Marshall R. / Oral Human Papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. In: Journal of Clinical Oncology. 2014 ; Vol. 32, No. 23. pp. 2408-2415.
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abstract = "Purpose: To better understand oral human papillomavirus (HPV) infection and cancer risk among long-term sexual partners of patients with HPV-positive oropharyngeal cancer (HPV-OPC). Patients and Methods: An oral rinse sample, risk factor survey, cancer history, and oral examination (partners only) were collected from patients with HPV-OPC and their partners. Oral rinse samples were evaluated for 36 types of HPV DNA using PGMY 09/11 primers and line-blot hybridization and HPV16 copy number using quantitative polymerase chain reaction. Oral HPV prevalence was compared with infection among those age 45 to 65 years using National Health and Nutrition Examination Survey (NHANES) 2009-2010. Results: A total of 164 patients with HPV-OPC and 93 of their partners were enrolled. Patients were primarily men (90{\%}), were never-smokers (51{\%}), and had performed oral sex (97{\%}), with a median age of 56 years; they had a high prevalence of oncogenic oral HPV DNA (61{\%}) and oral HPV16 DNA (54{\%}) at enrollment. Female partners had comparable oncogenic oral HPV prevalence compared with members of the general population of the same age (1.2{\%} v 1.3{\%}). Among the six male partners, no oncogenic oral HPV infections were detected. No precancers or cancers were identified during partner oral cancer screening examinations. However, a history of cervical disease was reported by nine partners (10.3{\%}) and two female patients (11.8{\%}), and three patients (2.0{\%}) reported a previous partner who developed invasive cervical cancer. Conclusion: Oral HPV16 DNA is commonly detected among patients with HPV-OPC at diagnosis, but not among their partners. Partners of patients with HPV-OPC do not seem to have elevated oral HPV infection compared with the general population.",
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AU - Gross, Neil D.

AU - Pai, Sara I.

AU - Haddad, Robert

AU - Anderson, Karen

AU - Rajan, Shirani

AU - Gerber, Jennifer

AU - Gillison, Maura L.

AU - Posner, Marshall R.

PY - 2014/8/10

Y1 - 2014/8/10

N2 - Purpose: To better understand oral human papillomavirus (HPV) infection and cancer risk among long-term sexual partners of patients with HPV-positive oropharyngeal cancer (HPV-OPC). Patients and Methods: An oral rinse sample, risk factor survey, cancer history, and oral examination (partners only) were collected from patients with HPV-OPC and their partners. Oral rinse samples were evaluated for 36 types of HPV DNA using PGMY 09/11 primers and line-blot hybridization and HPV16 copy number using quantitative polymerase chain reaction. Oral HPV prevalence was compared with infection among those age 45 to 65 years using National Health and Nutrition Examination Survey (NHANES) 2009-2010. Results: A total of 164 patients with HPV-OPC and 93 of their partners were enrolled. Patients were primarily men (90%), were never-smokers (51%), and had performed oral sex (97%), with a median age of 56 years; they had a high prevalence of oncogenic oral HPV DNA (61%) and oral HPV16 DNA (54%) at enrollment. Female partners had comparable oncogenic oral HPV prevalence compared with members of the general population of the same age (1.2% v 1.3%). Among the six male partners, no oncogenic oral HPV infections were detected. No precancers or cancers were identified during partner oral cancer screening examinations. However, a history of cervical disease was reported by nine partners (10.3%) and two female patients (11.8%), and three patients (2.0%) reported a previous partner who developed invasive cervical cancer. Conclusion: Oral HPV16 DNA is commonly detected among patients with HPV-OPC at diagnosis, but not among their partners. Partners of patients with HPV-OPC do not seem to have elevated oral HPV infection compared with the general population.

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