Optogenetic neurostimulation of auricular vagus using flexible OLED display technology to treat chronic inflammatory disease and mental health disorders

J. Smith; A. Shah; Y. K. Lee; B. O'Brien; D. Kullman; A. Sridharan; Jitendran Muthuswamy; Jennifer Blain Christen

doi:10.1049/el.2015.3450

Optogenetic neurostimulation of auricular vagus using flexible OLED display technology to treat chronic inflammatory disease and mental health disorders

J. Smith, A. Shah, Y. K. Lee, B. O'Brien, D. Kullman, A. Sridharan, Jitendran Muthuswamy, Jennifer Blain Christen

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The viability of a new biophotonic alternative to conventional prescription-drug-based treatments is explored for inflammatory disease and mental health disorders using a non-invasive drug-free optogeneticsbased therapy to treat patients by optically stimulating selected afferent branches of the auricular vagus nerve transcutaneously via the outer ear using a high-resolution, addressable array of organic light emitting diodes (OLED) manufactured on a flexible plastic substrate. Preliminary analysis and optical measurements indicate that our 620 nm flexible red OLED display technology is bright enough to induce therapeutic optical stimulation in optogenetically modified neural tissue.

Original language	English (US)
Pages (from-to)	900-902
Number of pages	3
Journal	Electronics Letters
Volume	52
Issue number	11
DOIs	https://doi.org/10.1049/el.2015.3450
State	Published - May 26 2016

ASJC Scopus subject areas

Electrical and Electronic Engineering

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abstract = "The viability of a new biophotonic alternative to conventional prescription-drug-based treatments is explored for inflammatory disease and mental health disorders using a non-invasive drug-free optogeneticsbased therapy to treat patients by optically stimulating selected afferent branches of the auricular vagus nerve transcutaneously via the outer ear using a high-resolution, addressable array of organic light emitting diodes (OLED) manufactured on a flexible plastic substrate. Preliminary analysis and optical measurements indicate that our 620 nm flexible red OLED display technology is bright enough to induce therapeutic optical stimulation in optogenetically modified neural tissue.",

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AU - Kullman, D.

AU - Sridharan, A.

AU - Muthuswamy, Jitendran

AU - Blain Christen, Jennifer

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AB - The viability of a new biophotonic alternative to conventional prescription-drug-based treatments is explored for inflammatory disease and mental health disorders using a non-invasive drug-free optogeneticsbased therapy to treat patients by optically stimulating selected afferent branches of the auricular vagus nerve transcutaneously via the outer ear using a high-resolution, addressable array of organic light emitting diodes (OLED) manufactured on a flexible plastic substrate. Preliminary analysis and optical measurements indicate that our 620 nm flexible red OLED display technology is bright enough to induce therapeutic optical stimulation in optogenetically modified neural tissue.

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Optogenetic neurostimulation of auricular vagus using flexible OLED display technology to treat chronic inflammatory disease and mental health disorders

Abstract

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