Optimization of Targeted Therapies to Inhibit Smooth Muscle Cell Invasion In Vitro

C. E. Kennedy, Stephen Massia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimai hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study tested three targeted therapies and their combinations: hyperfunctional α vβ 3 integrin expression, cyclic-RGD release and tissue inhibitor of metalloprotease (TIMP)-1 release. It was found that a combination of 1.0 mM cyclic-RGD and 10 ng/mL TIMP-1 maximally inhibited smooth muscle cell invasion over individual or other combinations of treatments over 72 hours.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1215-1218
Number of pages4
Volume2
StatePublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period9/17/039/21/03

Keywords

  • Hyperplasia
  • Integrin
  • Invasion
  • Migration
  • Peptide
  • Smooth muscle cells

ASJC Scopus subject areas

  • Bioengineering

Fingerprint Dive into the research topics of 'Optimization of Targeted Therapies to Inhibit Smooth Muscle Cell Invasion In Vitro'. Together they form a unique fingerprint.

  • Cite this

    Kennedy, C. E., & Massia, S. (2003). Optimization of Targeted Therapies to Inhibit Smooth Muscle Cell Invasion In Vitro. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1215-1218)