Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Christopher G. Cooney, Bruce C. Towe, Curt R. Eyster

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume69
Issue number1
DOIs
StatePublished - Sep 10 2000

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dioxides
Carbon Dioxide
carbon dioxide
Carbon dioxide
Buffers
Blood
Oxygen
blood
Monitoring
oxygen
buffers
Optical systems
Fluorescence
Flow rate
reagents
Sensors
flow velocity
fluorescence
sensors
Microdialysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry
  • Electrical and Electronic Engineering

Cite this

Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach. / Cooney, Christopher G.; Towe, Bruce C.; Eyster, Curt R.

In: Sensors and Actuators, B: Chemical, Vol. 69, No. 1, 10.09.2000, p. 183-188.

Research output: Contribution to journalArticle

Cooney, Christopher G. ; Towe, Bruce C. ; Eyster, Curt R. / Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach. In: Sensors and Actuators, B: Chemical. 2000 ; Vol. 69, No. 1. pp. 183-188.
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