Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Christopher G. Cooney; Bruce C. Towe; Curt R. Eyster

doi:10.1016/S0925-4005(00)00544-X

Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Christopher G. Cooney, Bruce C. Towe, Curt R. Eyster

Biological and Health Systems Engineering, School of (IAFSE-BHSE)

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO₂, and pO₂ in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO₂, and ±1.5 mm Hg pO₂ with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO₂, and pO₂, respectively.

Original language	English (US)
Pages (from-to)	183-188
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4005(00)00544-X
State	Published - Sep 10 2000

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

Access to Document

10.1016/S0925-4005(00)00544-X

Cite this

@article{4f4268be2a594da7a1de1b7bac399f85,

title = "Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach",

abstract = "Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.",

author = "Cooney, {Christopher G.} and Towe, {Bruce C.} and Eyster, {Curt R.}",

note = "Funding Information: This research is supported by NASA under grant NAG 9-821. ",

year = "2000",

month = sep,

day = "10",

doi = "10.1016/S0925-4005(00)00544-X",

language = "English (US)",

volume = "69",

pages = "183--188",

journal = "Sensors and Actuators, B: Chemical",

issn = "0925-4005",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

AU - Cooney, Christopher G.

AU - Towe, Bruce C.

AU - Eyster, Curt R.

N1 - Funding Information: This research is supported by NASA under grant NAG 9-821.

PY - 2000/9/10

Y1 - 2000/9/10

N2 - Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.

AB - Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0034273229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034273229&partnerID=8YFLogxK

U2 - 10.1016/S0925-4005(00)00544-X

DO - 10.1016/S0925-4005(00)00544-X

M3 - Article

AN - SCOPUS:0034273229

SN - 0925-4005

VL - 69

SP - 183

EP - 188

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

IS - 1

ER -

Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this