Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Christopher G. Cooney, Bruce C. Towe, Curt R. Eyster

Research output: Contribution to journalArticle

35 Scopus citations


Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalSensors and Actuators, B: Chemical
Issue number1
StatePublished - Sep 10 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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