Opiate control of spontaneous locomotor activity in a urodele amphibian

Pierre Deviche, Christopher A. Lowry, Frank L. Moore

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An intraperitoneal injection of the preferential opiate receptor agonist (±)bremazocine HCl given to male rough-skinned newts acutely and dose-dependently reduced their spontaneous locomotor activity. Inversely, and contrary to the situation generally observed in other vertebrates, administration of the opiate receptor antagonist naloxone HCl dose-dependently and acutely stimulated locomotion. Given at a behaviorally active dosage, naloxone counteracted the inhibitory effect of bremazocine on locomotion. The behavioral influence of the two substances was observed using two different sampling techniques (continuous recording for 3 minutes; repeated instantaneous sampling for 60 minutes). These data are discussed in view of our current knowledge on the opiate regulation of locomotor activity in vertebrates.

Original languageEnglish (US)
Pages (from-to)753-757
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume34
Issue number4
DOIs
StatePublished - Dec 1989
Externally publishedYes

Keywords

  • Amphibians
  • Bremazocine
  • Locomotion
  • Naloxone
  • Opiates

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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