Ontogenetic changes in [3H]-spiroperidol binding sites in posthatch chick brain

Sanders A. McDougall, Janet Neisewander, Michael T. Bardo, James F. Zolman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-days-posthatch, but no significant differences were found in either brain area across the initial four posthatch days. In the forebrain base, [3H]-spiroperidol receptor density and total binding increased significantly between 1- and 4-days-posthatch, but at 16-days-posthatch there was a slight decrease in receptor density. Binding sites in the forebrain roof were minimal at all ages. As expected, saturation experiments yielded curvilinear plots indicating the presence of high- and low-affinity binding sites. The high-affinity sites probably reflect dopamine D-2 receptors; whereas, the low-affinity sites may reflect other receptor types, possibly serotonin S-2. These results suggest that large doses of haloperidol, which are normally used in chick behavioral research, may produce behavioral effects by antagonizing multiple receptors.

Original languageEnglish (US)
Pages (from-to)1515-1520
Number of pages6
JournalLife Sciences
Volume44
Issue number20
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Spiperone
Prosencephalon
Brain
Binding Sites
Superior Colliculi
Roofs
Cerebellum
Optics
Behavioral research
Behavioral Research
Serotonin Receptors
Haloperidol
Dopamine
Experiments

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ontogenetic changes in [3H]-spiroperidol binding sites in posthatch chick brain. / McDougall, Sanders A.; Neisewander, Janet; Bardo, Michael T.; Zolman, James F.

In: Life Sciences, Vol. 44, No. 20, 1989, p. 1515-1520.

Research output: Contribution to journalArticle

McDougall, Sanders A. ; Neisewander, Janet ; Bardo, Michael T. ; Zolman, James F. / Ontogenetic changes in [3H]-spiroperidol binding sites in posthatch chick brain. In: Life Sciences. 1989 ; Vol. 44, No. 20. pp. 1515-1520.
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