Abstract

Various innovative chemical sensors have been developed in recent years to sense dangerous substances in air and trace biomarkers in breath. However, in order to solve real world problems, the sensors must be equipped with efficient sample conditioning that can, e.g., control the humidity, which is discussed much less in the literature. To meet the demand, a miniaturized mouthpiece was developed for personal breath analyzers. A key function of the mouthpiece is to condition the humidity in real breath samples without changing the analyte concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles. Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable parameters, such as the size, density, and geometry of the packing. Mouthpieces with different configurations were built and tested, and the experimental data validated the simulation findings. A mouthpiece with optimized performance reducing relative humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of this breath conditioning approach.

Original languageEnglish (US)
Pages (from-to)7172-7178
Number of pages7
JournalAnalytical Chemistry
Volume84
Issue number16
DOIs
StatePublished - Aug 21 2012

Fingerprint

Hygroscopic Agents
Atmospheric humidity
Nitric Oxide
Sensors
Chemiluminescence
Biomarkers
Acetone
Chemical sensors
Ammonia
Carbon Dioxide
Oxygen
Geometry
Computer simulation
Air

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Prabhakar, A., Iglesias, R. A., Shan, X., Xian, X., Zhang, L., Tsow, F., ... Tao, N. (2012). Online sample conditioning for portable breath analyzers. Analytical Chemistry, 84(16), 7172-7178. https://doi.org/10.1021/ac301542j

Online sample conditioning for portable breath analyzers. / Prabhakar, Amlendu; Iglesias, Rodrigo A.; Shan, Xiaonan; Xian, Xiaojun; Zhang, Lihua; Tsow, Francis; Forzani, Erica; Tao, Nongjian.

In: Analytical Chemistry, Vol. 84, No. 16, 21.08.2012, p. 7172-7178.

Research output: Contribution to journalArticle

Prabhakar, A, Iglesias, RA, Shan, X, Xian, X, Zhang, L, Tsow, F, Forzani, E & Tao, N 2012, 'Online sample conditioning for portable breath analyzers', Analytical Chemistry, vol. 84, no. 16, pp. 7172-7178. https://doi.org/10.1021/ac301542j
Prabhakar A, Iglesias RA, Shan X, Xian X, Zhang L, Tsow F et al. Online sample conditioning for portable breath analyzers. Analytical Chemistry. 2012 Aug 21;84(16):7172-7178. https://doi.org/10.1021/ac301542j
Prabhakar, Amlendu ; Iglesias, Rodrigo A. ; Shan, Xiaonan ; Xian, Xiaojun ; Zhang, Lihua ; Tsow, Francis ; Forzani, Erica ; Tao, Nongjian. / Online sample conditioning for portable breath analyzers. In: Analytical Chemistry. 2012 ; Vol. 84, No. 16. pp. 7172-7178.
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