On the relationship between evolution of virulence and host demography

Carlos Castillo-Chavez, Jorge X. Velasco-Hernández

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of density-dependence on the evolution of virulence in super-infection models is the theme of this paper. The qualitative dynamics of three host-pathogen systems are studied numerically in a virulence-superinfection parameter landscape. It is shown numerically that pathogen's competitive exclusion coexistence and host population extinction depend heavily on the population dynamics of the host population. Reported patterns of diversity found using models without demography, are insufficient to account for the coevolutionary dynamics under defined selective pressures. Specifically, virulence and superinfection in the presence of a variable host population give rise to threshold values that divide (as switches) the regions of coexistence and competitive exclusion. Tight coevolution on a variable host population may occur within regions of parameter space that are not connected. We present our numerical results using a simple host-disease system where a homogeneous host population is invaded by two competing pathogen strains (partial analytical results will be published elsewhere).

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalJournal of Theoretical Biology
Volume192
Issue number4
DOIs
StatePublished - Jun 21 1998
Externally publishedYes

Fingerprint

Demography
Pathogens
demography
Virulence
virulence
Competitive Exclusion
Superinfection
competitive exclusion
Population
Population dynamics
Coexistence
pathogens
Density Dependence
Switches
Coevolution
Population Dynamics
coevolution
Threshold Value
Extinction
Infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

On the relationship between evolution of virulence and host demography. / Castillo-Chavez, Carlos; Velasco-Hernández, Jorge X.

In: Journal of Theoretical Biology, Vol. 192, No. 4, 21.06.1998, p. 437-444.

Research output: Contribution to journalArticle

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