On the demographic and selective forces shaping patterns of human cytomegalovirus variation within hosts

Andrew M. Sackman, Susanne Pfeifer, Timothy F. Kowalik, Jeffrey Jensen

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is a member of the b-herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.

Original languageEnglish (US)
Article number16
JournalPathogens
Volume7
Issue number1
DOIs
StatePublished - Mar 2018

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Keywords

  • Human cytomegalovirus
  • Population genetics
  • Viral evolution

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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