On-chip cell culture biosensing with microfluidic feedback control

David Welch; Jennifer Blain Christen

doi:10.1109/LISSA.2011.5754150

On-chip cell culture biosensing with microfluidic feedback control

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

Original language	English (US)
Title of host publication	Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011
Pages	39-42
Number of pages	4
DOIs	https://doi.org/10.1109/LISSA.2011.5754150
State	Published - 2011
Event	2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011 - Bethesda, MD, United States Duration: Apr 7 2011 → Apr 8 2011

Publication series

Name	Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011

Other

Other	2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011
Country/Territory	United States
City	Bethesda, MD
Period	4/7/11 → 4/8/11

ASJC Scopus subject areas

Life-span and Life-course Studies

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10.1109/LISSA.2011.5754150

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On-chip cell culture biosensing with microfluidic feedback control. / Welch, David; Blain Christen, Jennifer.
Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011. 2011. p. 39-42 5754150 (Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Welch, D & Blain Christen, J 2011, On-chip cell culture biosensing with microfluidic feedback control. in Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011., 5754150, Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011, pp. 39-42, 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011, Bethesda, MD, United States, 4/7/11. https://doi.org/10.1109/LISSA.2011.5754150

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abstract = "We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.",

author = "David Welch and {Blain Christen}, Jennifer",

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doi = "10.1109/LISSA.2011.5754150",

language = "English (US)",

isbn = "9781457704208",

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AB - We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

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BT - Proceedings of the 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011

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On-chip cell culture biosensing with microfluidic feedback control

Abstract

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Other

ASJC Scopus subject areas

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