Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain

Kimberly T. Sibille, Christopher King, Timothy J. Garrett, Toni L. Glover, Hang Zhang, Huaihou Chen, Divya Reddy, Burel R. Goodin, Adriana Sotolongo, Megan Petrov, Yenisel Cruz-Almeida, Matthew Herbert, Emily J. Bartley, Jeffrey C. Edberg, Roland Staud, David T. Redden, Laurence A. Bradley, Roger B. Fillingim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVES:: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA. Based on recommended and typical ranges of the n-6:n-3 ratio, we hypothesized that in adults with knee pain, those with a high n-6:n-3 ratio would have greater pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to those with a low n-6:n-3 ratio. METHODS:: A cross-sectional investigation of clinical and experimental pain and physical and psychosocial functioning was completed in 167 adults ages 45-85 meeting knee OA screening criteria. Blood samples were collected and the plasma n-6:n-3 PUFA ratio determined. Quartile splits were computed and low (n=42) and high (n=41) ratio groups were compared. RESULTS:: The high ratio group reported greater pain and functional limitations, (all P’s<0.04), mechanical temporal summation (hand and knee, P<0.05), and perceived stress (P=0.008) but not depressive symptoms. DISCUSSION:: In adults with knee pain, a high n-6:n-3 ratio is associated with greater clinical pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to a low ratio group. Findings support consideration of the n-6:n-3 PUFA ratio and additional clinical endpoints in future research efforts.

Original languageEnglish (US)
JournalClinical Journal of Pain
DOIs
StateAccepted/In press - May 24 2017

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Omega-3 Fatty Acids
Unsaturated Fatty Acids
Knee
Pain
Nociception
Knee Osteoarthritis
Osteoarthritis
Inflammation
Chronic Pain
Fatty Acids
Hand
Outcome Assessment (Health Care)
Depression
Psychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Sibille, K. T., King, C., Garrett, T. J., Glover, T. L., Zhang, H., Chen, H., ... Fillingim, R. B. (Accepted/In press). Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain. Clinical Journal of Pain. https://doi.org/10.1097/AJP.0000000000000517

Omega-6 : Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain. / Sibille, Kimberly T.; King, Christopher; Garrett, Timothy J.; Glover, Toni L.; Zhang, Hang; Chen, Huaihou; Reddy, Divya; Goodin, Burel R.; Sotolongo, Adriana; Petrov, Megan; Cruz-Almeida, Yenisel; Herbert, Matthew; Bartley, Emily J.; Edberg, Jeffrey C.; Staud, Roland; Redden, David T.; Bradley, Laurence A.; Fillingim, Roger B.

In: Clinical Journal of Pain, 24.05.2017.

Research output: Contribution to journalArticle

Sibille, KT, King, C, Garrett, TJ, Glover, TL, Zhang, H, Chen, H, Reddy, D, Goodin, BR, Sotolongo, A, Petrov, M, Cruz-Almeida, Y, Herbert, M, Bartley, EJ, Edberg, JC, Staud, R, Redden, DT, Bradley, LA & Fillingim, RB 2017, 'Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain', Clinical Journal of Pain. https://doi.org/10.1097/AJP.0000000000000517
Sibille, Kimberly T. ; King, Christopher ; Garrett, Timothy J. ; Glover, Toni L. ; Zhang, Hang ; Chen, Huaihou ; Reddy, Divya ; Goodin, Burel R. ; Sotolongo, Adriana ; Petrov, Megan ; Cruz-Almeida, Yenisel ; Herbert, Matthew ; Bartley, Emily J. ; Edberg, Jeffrey C. ; Staud, Roland ; Redden, David T. ; Bradley, Laurence A. ; Fillingim, Roger B. / Omega-6 : Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain. In: Clinical Journal of Pain. 2017.
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abstract = "OBJECTIVES:: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA. Based on recommended and typical ranges of the n-6:n-3 ratio, we hypothesized that in adults with knee pain, those with a high n-6:n-3 ratio would have greater pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to those with a low n-6:n-3 ratio. METHODS:: A cross-sectional investigation of clinical and experimental pain and physical and psychosocial functioning was completed in 167 adults ages 45-85 meeting knee OA screening criteria. Blood samples were collected and the plasma n-6:n-3 PUFA ratio determined. Quartile splits were computed and low (n=42) and high (n=41) ratio groups were compared. RESULTS:: The high ratio group reported greater pain and functional limitations, (all P’s<0.04), mechanical temporal summation (hand and knee, P<0.05), and perceived stress (P=0.008) but not depressive symptoms. DISCUSSION:: In adults with knee pain, a high n-6:n-3 ratio is associated with greater clinical pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to a low ratio group. Findings support consideration of the n-6:n-3 PUFA ratio and additional clinical endpoints in future research efforts.",
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AU - Sibille, Kimberly T.

AU - King, Christopher

AU - Garrett, Timothy J.

AU - Glover, Toni L.

AU - Zhang, Hang

AU - Chen, Huaihou

AU - Reddy, Divya

AU - Goodin, Burel R.

AU - Sotolongo, Adriana

AU - Petrov, Megan

AU - Cruz-Almeida, Yenisel

AU - Herbert, Matthew

AU - Bartley, Emily J.

AU - Edberg, Jeffrey C.

AU - Staud, Roland

AU - Redden, David T.

AU - Bradley, Laurence A.

AU - Fillingim, Roger B.

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N2 - OBJECTIVES:: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA. Based on recommended and typical ranges of the n-6:n-3 ratio, we hypothesized that in adults with knee pain, those with a high n-6:n-3 ratio would have greater pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to those with a low n-6:n-3 ratio. METHODS:: A cross-sectional investigation of clinical and experimental pain and physical and psychosocial functioning was completed in 167 adults ages 45-85 meeting knee OA screening criteria. Blood samples were collected and the plasma n-6:n-3 PUFA ratio determined. Quartile splits were computed and low (n=42) and high (n=41) ratio groups were compared. RESULTS:: The high ratio group reported greater pain and functional limitations, (all P’s<0.04), mechanical temporal summation (hand and knee, P<0.05), and perceived stress (P=0.008) but not depressive symptoms. DISCUSSION:: In adults with knee pain, a high n-6:n-3 ratio is associated with greater clinical pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to a low ratio group. Findings support consideration of the n-6:n-3 PUFA ratio and additional clinical endpoints in future research efforts.

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