Occipital cortico-pyramidal projection in hypothyroid rats

Chi Pei Li, Jaime F. Olavarria, Bradley Greger

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalDevelopmental Brain Research
Volume89
Issue number2
DOIs
StatePublished - Nov 21 1995
Externally publishedYes

Fingerprint

Thiouracil
Hypothyroidism
Antithyroid Agents
Pyramidal Tracts
Visual Cortex
Horseradish Peroxidase
Maintenance

Keywords

  • Collateral elimination
  • Pyramidal tract
  • Thyroid hormone
  • Transient projection
  • Visual cortex

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Occipital cortico-pyramidal projection in hypothyroid rats. / Li, Chi Pei; Olavarria, Jaime F.; Greger, Bradley.

In: Developmental Brain Research, Vol. 89, No. 2, 21.11.1995, p. 227-234.

Research output: Contribution to journalArticle

Li, Chi Pei ; Olavarria, Jaime F. ; Greger, Bradley. / Occipital cortico-pyramidal projection in hypothyroid rats. In: Developmental Brain Research. 1995 ; Vol. 89, No. 2. pp. 227-234.
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