Obesity in neurobiology

Stefan Knecht, Tanja Ellger, James A. Levine

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Obesity reflects an imbalance between energy uptake and expenditure that is mediated by behavior. Obesity is a growing epidemic and a major risk factor for neurobiological diseases like stroke, dementia, intracranial hypertension and sleep disorders. Conversely, obesity can also be induced by neurobiological disorders and drugs. The etiology of obesity is complex and includes biology, behavior and environment. Physicians are faced with the need to manage obesity while strategies for prevention and sustained weight reduction are limited. Present treatment options comprise lifestyle modification, diet, pharmacotherapy and bariatric surgery. Considerable headway has been made into elucidating the neurobiological underpinnings of obesogenic behavior. There is now a growing understanding of the metabolic, hormonal and behavioral circuitries that contribute to the complex and redundant system for energy balance. Changing the net balance of this system to prevent or reduce obesity requires multimodal and long-term interventions.

Original languageEnglish (US)
Pages (from-to)85-103
Number of pages19
JournalProgress in Neurobiology
Volume84
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Neurobiology
Obesity
Diet Therapy
Intracranial Hypertension
Bariatric Surgery
Energy Metabolism
Dementia
Life Style
Weight Loss
Stroke
Physicians
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Behavior
  • Endocrinology
  • Neurocognition
  • Neurology
  • Obesity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Knecht, S., Ellger, T., & Levine, J. A. (2008). Obesity in neurobiology. Progress in Neurobiology, 84(1), 85-103. https://doi.org/10.1016/j.pneurobio.2007.09.003

Obesity in neurobiology. / Knecht, Stefan; Ellger, Tanja; Levine, James A.

In: Progress in Neurobiology, Vol. 84, No. 1, 01.2008, p. 85-103.

Research output: Contribution to journalArticle

Knecht, S, Ellger, T & Levine, JA 2008, 'Obesity in neurobiology', Progress in Neurobiology, vol. 84, no. 1, pp. 85-103. https://doi.org/10.1016/j.pneurobio.2007.09.003
Knecht, Stefan ; Ellger, Tanja ; Levine, James A. / Obesity in neurobiology. In: Progress in Neurobiology. 2008 ; Vol. 84, No. 1. pp. 85-103.
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