Nucleotide substitutions and the evolution of duplicate genes.

J. S. Conery, Michael Lynch

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Duplicate Genes
Codon
Nucleotides
Gene Duplication
Genetic Selection
Amino Acid Sequence
Software
Genome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nucleotide substitutions and the evolution of duplicate genes. / Conery, J. S.; Lynch, Michael.

In: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 01.01.2001, p. 167-178.

Research output: Contribution to journalArticle

@article{336213c83296431a97335cee62a424c9,
title = "Nucleotide substitutions and the evolution of duplicate genes.",
abstract = "This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.",
author = "Conery, {J. S.} and Michael Lynch",
year = "2001",
month = "1",
day = "1",
language = "English (US)",
pages = "167--178",
journal = "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing",
issn = "2335-6936",

}

TY - JOUR

T1 - Nucleotide substitutions and the evolution of duplicate genes.

AU - Conery, J. S.

AU - Lynch, Michael

PY - 2001/1/1

Y1 - 2001/1/1

N2 - This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.

AB - This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.

UR - http://www.scopus.com/inward/record.url?scp=0035222174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035222174&partnerID=8YFLogxK

M3 - Article

C2 - 11262937

AN - SCOPUS:0035222174

SP - 167

EP - 178

JO - Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

JF - Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

SN - 2335-6936

ER -