Nucleotide substitutions and the evolution of duplicate genes.

J. S. Conery, M. Lynch

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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