Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis

Haiwei Gu, Yun Peng Qi, Ning Xu, Jian Hua Ding, Yan Bo An, Huan Wen Chen

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

It is highly desirable to develop and validate novel methods for detecting cancer with higher sensitivity and better specificity. The aim of this review is to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We briefly introduced the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have demonstrated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we discussed the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.

Original languageEnglish (US)
Pages (from-to)1933-1937
Number of pages5
JournalFenxi Huaxue/ Chinese Journal of Analytical Chemistry
Volume40
Issue number12
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Nuclear magnetic resonance spectroscopy
Mass spectrometry
Metabolites
Metabolomics
Blood
Tissue
Molecules
Monitoring
Pharmaceutical Preparations

Keywords

  • Cancer
  • Diagnosis
  • Mass spectrometry
  • Metabolic profiling
  • Metabolomics
  • Nuclear magnetic resonance spectroscopy
  • Oncology
  • Review

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis. / Gu, Haiwei; Qi, Yun Peng; Xu, Ning; Ding, Jian Hua; An, Yan Bo; Chen, Huan Wen.

In: Fenxi Huaxue/ Chinese Journal of Analytical Chemistry, Vol. 40, No. 12, 01.01.2012, p. 1933-1937.

Research output: Contribution to journalReview article

Gu, Haiwei ; Qi, Yun Peng ; Xu, Ning ; Ding, Jian Hua ; An, Yan Bo ; Chen, Huan Wen. / Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis. In: Fenxi Huaxue/ Chinese Journal of Analytical Chemistry. 2012 ; Vol. 40, No. 12. pp. 1933-1937.
@article{6f2d540b87204c5095137f1e054ed139,
title = "Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis",
abstract = "It is highly desirable to develop and validate novel methods for detecting cancer with higher sensitivity and better specificity. The aim of this review is to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We briefly introduced the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have demonstrated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we discussed the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.",
keywords = "Cancer, Diagnosis, Mass spectrometry, Metabolic profiling, Metabolomics, Nuclear magnetic resonance spectroscopy, Oncology, Review",
author = "Haiwei Gu and Qi, {Yun Peng} and Ning Xu and Ding, {Jian Hua} and An, {Yan Bo} and Chen, {Huan Wen}",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/S1872-2040(11)60594-X",
language = "English (US)",
volume = "40",
pages = "1933--1937",
journal = "Chinese Journal of Analytical Chemistry",
issn = "1872-2040",
publisher = "Elsevier BV",
number = "12",

}

TY - JOUR

T1 - Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis

AU - Gu, Haiwei

AU - Qi, Yun Peng

AU - Xu, Ning

AU - Ding, Jian Hua

AU - An, Yan Bo

AU - Chen, Huan Wen

PY - 2012/1/1

Y1 - 2012/1/1

N2 - It is highly desirable to develop and validate novel methods for detecting cancer with higher sensitivity and better specificity. The aim of this review is to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We briefly introduced the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have demonstrated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we discussed the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.

AB - It is highly desirable to develop and validate novel methods for detecting cancer with higher sensitivity and better specificity. The aim of this review is to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We briefly introduced the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have demonstrated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we discussed the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.

KW - Cancer

KW - Diagnosis

KW - Mass spectrometry

KW - Metabolic profiling

KW - Metabolomics

KW - Nuclear magnetic resonance spectroscopy

KW - Oncology

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=84872113772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872113772&partnerID=8YFLogxK

U2 - 10.1016/S1872-2040(11)60594-X

DO - 10.1016/S1872-2040(11)60594-X

M3 - Review article

AN - SCOPUS:84872113772

VL - 40

SP - 1933

EP - 1937

JO - Chinese Journal of Analytical Chemistry

JF - Chinese Journal of Analytical Chemistry

SN - 1872-2040

IS - 12

ER -