TY - JOUR
T1 - N6-(Δ2-isopentenyl)adenosine
T2 - The regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes
AU - Gallo, Robert C.
AU - Hecht, Sidney M.
AU - Whang-Peng, Jacqueline
AU - O'Hopp, Susan
PY - 1972/11/9
Y1 - 1972/11/9
N2 - We have studied the effects of N6-(Δ2-isopentenyl)adenosine and related cytokinin analogs on the stimulation and inhibition of phytohemagglutinin-induced growth of human lymphocytes. We have found that N6-(Δ2-isopentenyl)adenosine exerts inhibitory effects on RNA synthesis, uridine transport and uridylate kinase synthesis. On the basis of the interaction of N6-(Δ2-isopentenyl)adenosine with cyclic AMP in this system, we propose that the observed stimulatory and inhibitory effects may be due to the involvement of N6-(Δ2-isopentenyl)adenosine in cyclic AMP metabolism.
AB - We have studied the effects of N6-(Δ2-isopentenyl)adenosine and related cytokinin analogs on the stimulation and inhibition of phytohemagglutinin-induced growth of human lymphocytes. We have found that N6-(Δ2-isopentenyl)adenosine exerts inhibitory effects on RNA synthesis, uridine transport and uridylate kinase synthesis. On the basis of the interaction of N6-(Δ2-isopentenyl)adenosine with cyclic AMP in this system, we propose that the observed stimulatory and inhibitory effects may be due to the involvement of N6-(Δ2-isopentenyl)adenosine in cyclic AMP metabolism.
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U2 - 10.1016/0005-2787(72)90149-9
DO - 10.1016/0005-2787(72)90149-9
M3 - Article
C2 - 4653127
AN - SCOPUS:0015499572
SN - 0005-2787
VL - 281
SP - 488
EP - 500
JO - BBA Section Nucleic Acids And Protein Synthesis
JF - BBA Section Nucleic Acids And Protein Synthesis
IS - 4
ER -