Novel tunable DNA-nanostructure vaccines against drugs of abuse

Yung Chang (Inventor), Sidney Hecht (Inventor), Hao Yan (Inventor)

Research output: Patent

Abstract

Drugs of abuse are highly addictive, and even if users are aware of the health risks, there is significant difficulty in ending their use because of dependency. Nicotine, the principle addictive component in cigarettes, is a prime example of a wide-spread addictive drug. Latest studies report that 19% of adult Americans smoke cigarettes, despite the wealth of evidence showing their detrimental health effects (CDC National Health Interview Survey, 2011). Researchers at the Biodesign Institute of Arizona State University have developed novel DNA-nanostructure based vaccines against drugs of abuse such as nicotine, cocaine and amphetamines. These vaccines will induce the anti-nicotine antibody production to sequester nicotine from rapidly getting into the brain, and therefore to reduce addiction effect. Preliminary data in a mouse model show that a DNA-Nicotine vaccine complex induces anti-nicotine antibody production. These rationally designed, spatially addressable DNA-nanostructures make vaccine development more robust, efficient and possibly less costly than conventional strategies, and may have the potential to significantly curb substance abuse. Potential Applications Inducing active immunity against targets of interest such as: Drugs of abuse including nicotine, cocaine, amphetamines, etc. Tumor antigens Infectious agents Benefits and Advantages Robust and versatile self-assembly with step-wise in vitro screening procedures enable quick and systematic identification of optimal configurations Well defined spatial distance and orientations can be optimized for inter-molecular interactions and to effectively induce an antibody response More robust and efficient than conventional strategies - induces more potent immunity against target antigens Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Yan's departmental webpage Dr. Yan's departmental webpage Dr. Chang's directory webpage Dr. Chang's departmental webpage
Original languageEnglish (US)
Publication statusPublished - Feb 15 2013

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