Novel Therapeutic Agent & Method for Selectively Inducing Apoptosis in Cancer Cells

Bertram Jacobs (Inventor)

Research output: Patent

Abstract

Many anti-cancer agents work by making cancer cells commit suicide (apoptosis). In fact, induction of apoptosis is a major treatment for cancer. Over time, however, many cancers become resistant to the apoptotic effects of the anti-cancer agents, which leads to ultimate failure of the treatment. Another problem with using previously known agents is that they may cause apoptosis in both cancer cells and normal cells. Researchers at Arizona State University have been investigating induction of apoptosis in cancer cells through new approaches using a novel virus induced agent. This agent induces apoptosis in a very different manner from most other known anti-cancer agents. It appears to induce apoptosis even in cancer cells that have become resistant to treatment with many traditional anti-cancer agents. Moreover, part of this new invention is a treatment method which causes the agent to be produced only in cancer cells, thus allowing specific killing of cancer cells while minimizing injury to normal cells in the body. Tumors could then be appropriately treated, which would specifically kill the cancer cells without harming surrounding normal cells.This invention is also not limited to induction of apoptosis in cancer cells, but might include induction of apoptosis specifically in virus-infected cells, or cells infected with other agents, or in uninfected cells.
Original languageEnglish (US)
StatePublished - Jan 1 1900

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Apoptosis
Neoplasms
Therapeutics
Viruses
Treatment Failure
Suicide
Research Personnel
Wounds and Injuries

Cite this

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title = "Novel Therapeutic Agent & Method for Selectively Inducing Apoptosis in Cancer Cells",
abstract = "Many anti-cancer agents work by making cancer cells commit suicide (apoptosis). In fact, induction of apoptosis is a major treatment for cancer. Over time, however, many cancers become resistant to the apoptotic effects of the anti-cancer agents, which leads to ultimate failure of the treatment. Another problem with using previously known agents is that they may cause apoptosis in both cancer cells and normal cells. Researchers at Arizona State University have been investigating induction of apoptosis in cancer cells through new approaches using a novel virus induced agent. This agent induces apoptosis in a very different manner from most other known anti-cancer agents. It appears to induce apoptosis even in cancer cells that have become resistant to treatment with many traditional anti-cancer agents. Moreover, part of this new invention is a treatment method which causes the agent to be produced only in cancer cells, thus allowing specific killing of cancer cells while minimizing injury to normal cells in the body. Tumors could then be appropriately treated, which would specifically kill the cancer cells without harming surrounding normal cells.This invention is also not limited to induction of apoptosis in cancer cells, but might include induction of apoptosis specifically in virus-infected cells, or cells infected with other agents, or in uninfected cells.",
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year = "1900",
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N2 - Many anti-cancer agents work by making cancer cells commit suicide (apoptosis). In fact, induction of apoptosis is a major treatment for cancer. Over time, however, many cancers become resistant to the apoptotic effects of the anti-cancer agents, which leads to ultimate failure of the treatment. Another problem with using previously known agents is that they may cause apoptosis in both cancer cells and normal cells. Researchers at Arizona State University have been investigating induction of apoptosis in cancer cells through new approaches using a novel virus induced agent. This agent induces apoptosis in a very different manner from most other known anti-cancer agents. It appears to induce apoptosis even in cancer cells that have become resistant to treatment with many traditional anti-cancer agents. Moreover, part of this new invention is a treatment method which causes the agent to be produced only in cancer cells, thus allowing specific killing of cancer cells while minimizing injury to normal cells in the body. Tumors could then be appropriately treated, which would specifically kill the cancer cells without harming surrounding normal cells.This invention is also not limited to induction of apoptosis in cancer cells, but might include induction of apoptosis specifically in virus-infected cells, or cells infected with other agents, or in uninfected cells.

AB - Many anti-cancer agents work by making cancer cells commit suicide (apoptosis). In fact, induction of apoptosis is a major treatment for cancer. Over time, however, many cancers become resistant to the apoptotic effects of the anti-cancer agents, which leads to ultimate failure of the treatment. Another problem with using previously known agents is that they may cause apoptosis in both cancer cells and normal cells. Researchers at Arizona State University have been investigating induction of apoptosis in cancer cells through new approaches using a novel virus induced agent. This agent induces apoptosis in a very different manner from most other known anti-cancer agents. It appears to induce apoptosis even in cancer cells that have become resistant to treatment with many traditional anti-cancer agents. Moreover, part of this new invention is a treatment method which causes the agent to be produced only in cancer cells, thus allowing specific killing of cancer cells while minimizing injury to normal cells in the body. Tumors could then be appropriately treated, which would specifically kill the cancer cells without harming surrounding normal cells.This invention is also not limited to induction of apoptosis in cancer cells, but might include induction of apoptosis specifically in virus-infected cells, or cells infected with other agents, or in uninfected cells.

M3 - Patent

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