Novel cytotoxic diterpenes from Casearia arborea

John A. Beutler; Kate L. McCall; Kathryn Herbert; Delbert L. Herald; George Pettit; Tanya Johnson; Robert H. Shoemaker; Michael R. Boyd

doi:10.1021/np990553r

Novel cytotoxic diterpenes from Casearia arborea

John A. Beutler, Kate L. McCall, Kathryn Herbert, Delbert L. Herald, George Pettit, Tanya Johnson, Robert H. Shoemaker, Michael R. Boyd

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

Original language	English (US)
Pages (from-to)	657-661
Number of pages	5
Journal	Journal of Natural Products
Volume	63
Issue number	5
DOIs	https://doi.org/10.1021/np990553r
State	Published - May 2000

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np990553r

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title = "Novel cytotoxic diterpenes from Casearia arborea",

abstract = "Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.",

author = "Beutler, {John A.} and McCall, {Kate L.} and Kathryn Herbert and Herald, {Delbert L.} and George Pettit and Tanya Johnson and Shoemaker, {Robert H.} and Boyd, {Michael R.}",

year = "2000",

month = may,

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AU - Beutler, John A.

AU - McCall, Kate L.

AU - Herbert, Kathryn

AU - Herald, Delbert L.

AU - Pettit, George

AU - Johnson, Tanya

AU - Shoemaker, Robert H.

AU - Boyd, Michael R.

PY - 2000/5

Y1 - 2000/5

N2 - Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

AB - Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

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Novel cytotoxic diterpenes from Casearia arborea

Abstract

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CCDC 145893: Experimental Crystal Structure Determination

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Novel cytotoxic diterpenes from Casearia arborea

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 145893: Experimental Crystal Structure Determination

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