Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Shoemaker, R. H. (Contributor), Johnson, T. (Contributor), Herbert, K. (Contributor), McCall, K. L. (Contributor), Beutler, J. A. (Contributor), Herald, D. L. (Contributor), Boyd, M. R. (Contributor) & Pettit, G. R. (Contributor), The Cambridge Structural Database, Jan 1 2000