Novel cytotoxic diterpenes from Casearia arborea

John A. Beutler, Kate L. McCall, Kathryn Herbert, Delbert L. Herald, George Pettit, Tanya Johnson, Robert H. Shoemaker, Michael R. Boyd

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

Original languageEnglish (US)
Pages (from-to)657-661
Number of pages5
JournalJournal of Natural Products
Volume63
Issue number5
DOIs
StatePublished - May 1 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Beutler, J. A., McCall, K. L., Herbert, K., Herald, D. L., Pettit, G., Johnson, T., Shoemaker, R. H., & Boyd, M. R. (2000). Novel cytotoxic diterpenes from Casearia arborea. Journal of Natural Products, 63(5), 657-661. https://doi.org/10.1021/np990553r