Nosocomial Legionella micdadei pneumonia

10 years experience and a case-control study

Bradley Doebbeling, Magued A. Ishak, Barbara H. Wade, Michael A. Pasquale, Robert E. Gerszten, Dieter H M Gröschel, Robert J. Kadner, Richard P. Wenzel

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Sixteen patients with nosocomial Legionella micdadei pneumonia, diagnosed between 1977 and 1988, were studied retrospectively to define clinical and epidemiological characteristics of the disease. Also, a case-control study was performed comparing the five patients with L. micdadei pneumonia during a cluster of cases in 1982, with uninfected patients with the same underlying diagnoses. No significant differences were noted in the case-control study with regard to age, presence of leucopenia, intensity or duration of immunosuppressive therapy, bed location, duration of hospital stay, frequency of transplant rejection or overall mortality. Legionella micdadei isolates from a sink on the renal transport ward, from hot water storage tanks, and one clinical isolate had identical cellular fatty acid composition. Extensive sampling of other potential sources failed to yield the organism. This indirect evidence suggests potable water as the source of infection.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalJournal of Hospital Infection
Volume13
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Legionella
Case-Control Studies
Pneumonia
Leukopenia
Graft Rejection
Immunosuppressive Agents
Drinking Water
Length of Stay
Fatty Acids
Kidney
Mortality
Water
Infection
Therapeutics

Keywords

  • epidemiology
  • hospital-acquired L. micdadei
  • nosocomial legionellosis
  • Pittsburgh pneumonia agent

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Doebbeling, B., Ishak, M. A., Wade, B. H., Pasquale, M. A., Gerszten, R. E., Gröschel, D. H. M., ... Wenzel, R. P. (1989). Nosocomial Legionella micdadei pneumonia: 10 years experience and a case-control study. Journal of Hospital Infection, 13(3), 289-298. https://doi.org/10.1016/0195-6701(89)90010-8

Nosocomial Legionella micdadei pneumonia : 10 years experience and a case-control study. / Doebbeling, Bradley; Ishak, Magued A.; Wade, Barbara H.; Pasquale, Michael A.; Gerszten, Robert E.; Gröschel, Dieter H M; Kadner, Robert J.; Wenzel, Richard P.

In: Journal of Hospital Infection, Vol. 13, No. 3, 1989, p. 289-298.

Research output: Contribution to journalArticle

Doebbeling, B, Ishak, MA, Wade, BH, Pasquale, MA, Gerszten, RE, Gröschel, DHM, Kadner, RJ & Wenzel, RP 1989, 'Nosocomial Legionella micdadei pneumonia: 10 years experience and a case-control study', Journal of Hospital Infection, vol. 13, no. 3, pp. 289-298. https://doi.org/10.1016/0195-6701(89)90010-8
Doebbeling, Bradley ; Ishak, Magued A. ; Wade, Barbara H. ; Pasquale, Michael A. ; Gerszten, Robert E. ; Gröschel, Dieter H M ; Kadner, Robert J. ; Wenzel, Richard P. / Nosocomial Legionella micdadei pneumonia : 10 years experience and a case-control study. In: Journal of Hospital Infection. 1989 ; Vol. 13, No. 3. pp. 289-298.
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