Nonsteroidal antiinflammatory drugs, eicosanoids, and colorectal cancer prevention

R. N. DuBois, F. M. Giardiello, W. E. Smalley

    Research output: Contribution to journalArticlepeer-review

    215 Scopus citations


    Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be one of the most affective class of chemoprotective agents to date. Most of the published studies have evaluated gastrointestinal malignancies. Here the authors review the clinical, epidemiologic, and laboratory data evaluating the affects of NSAIDs in cancer prevention. The authors hope that through a rigorous evaluation of past work and future experimentation the molecular basis for cancer chemoprevention by these agents will be understood.

    Original languageEnglish (US)
    Pages (from-to)773-791
    Number of pages19
    JournalGastroenterology Clinics of North America
    Issue number4
    StatePublished - 1996

    ASJC Scopus subject areas

    • Gastroenterology

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