TY - JOUR
T1 - Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention
AU - DuBois, R. N.
PY - 2001/2/6
Y1 - 2001/2/6
N2 - Colorectal cancer is the second leading cause of cancer deaths in the United States. Despite proven screening strategies, less than 40% of eligible Americans undergo appropriate screening for colorectal cancer. Research evaluating the underlying defects responsible for hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis has provided insight into some of the molecular mechanisms responsible for familial and sporadic colorectal cancer. The signaling pathways involved in the development of colorectal cancer may provide effective targets for prevention and treatment. These targets include cyclooxygenase-2, peroxisome proliferator activated receptor- δ, peroxisome proliferator activated receptor- γ, transforming growth factor- β receptors, and the inducible-nitric oxide synthase.
AB - Colorectal cancer is the second leading cause of cancer deaths in the United States. Despite proven screening strategies, less than 40% of eligible Americans undergo appropriate screening for colorectal cancer. Research evaluating the underlying defects responsible for hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis has provided insight into some of the molecular mechanisms responsible for familial and sporadic colorectal cancer. The signaling pathways involved in the development of colorectal cancer may provide effective targets for prevention and treatment. These targets include cyclooxygenase-2, peroxisome proliferator activated receptor- δ, peroxisome proliferator activated receptor- γ, transforming growth factor- β receptors, and the inducible-nitric oxide synthase.
UR - http://www.scopus.com/inward/record.url?scp=0035141681&partnerID=8YFLogxK
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U2 - 10.1097/00001574-200101000-00013
DO - 10.1097/00001574-200101000-00013
M3 - Review article
C2 - 17031153
AN - SCOPUS:0035141681
SN - 0267-1379
VL - 17
SP - 65
EP - 71
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 1
ER -