Nonrecombinant and recombinant avirulent Salmonella vaccines for poultry

Roy Curtiss, Jubril Olu Hassan

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We have constructed and evaluated a live avirulent Salmonella typhimurium vaccine strain, attenuated by deletion (Δ) mutations in genes for adenylate cyclase (cya) and the cAMP receptor protein (crp). Immunization of chicks can preclude Salmonella colonization and invasion of challenged vaccinated chickens when compared with the non vaccinated control. Immunization induces significant cross-protective immunity against various Salmonella serotypes and protects laying hens from transmission of Salmonella in or on eggs following challenge with S. enteritidis or S. typhimurium. Immunization of chicks destined to be breeders and then with a booster immunization at 16-18 weeks of age leads to maternal transfer of immunity to chicks which then can be immunized either orally or by coarse spray to display an enhanced immunity to prevent infection of visceral organs by and shedding of Salmonella. The attenuated S. typhimurium vaccine can be genetically manipulated to express foreign antigens specified by cloned genes from other pathogens. Immunization with such recombinant vaccines not only induces immunity to Salmonella but to infection by the pathogen that supplied the genes specifying the protective antigens expressed by the recombinant vaccine.

Original languageEnglish (US)
Pages (from-to)365-372
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume54
Issue number1-4
DOIs
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Salmonella Vaccines
Poultry
Salmonella
Immunity
Immunization
poultry
Salmonella typhimurium
vaccines
immunization
Synthetic Vaccines
Salmonella Typhimurium
immunity
chicks
recombinant vaccines
Cyclic AMP Receptor Protein
Genes
Secondary Immunization
Antigens
Attenuated Vaccines
cross immunity

Keywords

  • chickens
  • cross-protective immunity
  • maternal immunity
  • Salmonella vaccine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Nonrecombinant and recombinant avirulent Salmonella vaccines for poultry. / Curtiss, Roy; Hassan, Jubril Olu.

In: Veterinary Immunology and Immunopathology, Vol. 54, No. 1-4, 11.1996, p. 365-372.

Research output: Contribution to journalArticle

Curtiss, Roy ; Hassan, Jubril Olu. / Nonrecombinant and recombinant avirulent Salmonella vaccines for poultry. In: Veterinary Immunology and Immunopathology. 1996 ; Vol. 54, No. 1-4. pp. 365-372.
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