Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene

J. Theilm Ann, S. Kanani, R. Shiang, C. Robbins, O. Quarrell, M. Huggins, A. Hedrick, B. Weber, C. Collins, J. J. Wasmuth, Kenneth Buetow, J. C. Murray, M. R. Hayden

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Analysis of many families with linked DNA markers has provided support for the Huntington's disease (HD) gene being close to the telomere on the short arm of chromosome 4. However, analysis of recombination events in particular families has provided conflicting results about the precise location of the HD gene relative to these closely linked DNA markers. Here we report an investigation of linkage disequilibrium between six DNA markers and the HD gene in 75 separate families of varied ancestry. We show significant non-random association between alleles detected at D4S95 and D4S98 and the mutant gene. These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. This information may be helpful in defining a strategy to clone the gene for HD based on its location in the human genome.

Original languageEnglish (US)
Pages (from-to)676-681
Number of pages6
JournalJournal of Medical Genetics
Volume26
Issue number11
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Huntington Disease
Alleles
Disease
Genetic Markers
Genes
genetic test
Chromosomes, Human, Pair 4
Telomere
Linkage Disequilibrium
Genetic Counseling
Human Genome
Haplotypes
Genetic Recombination
counseling
Clone Cells
event
DNA
evidence

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Genetics
  • Genetics(clinical)

Cite this

Ann, J. T., Kanani, S., Shiang, R., Robbins, C., Quarrell, O., Huggins, M., ... Hayden, M. R. (1989). Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene. Journal of Medical Genetics, 26(11), 676-681. https://doi.org/10.1136/jmg.26.11.676

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene. / Ann, J. Theilm; Kanani, S.; Shiang, R.; Robbins, C.; Quarrell, O.; Huggins, M.; Hedrick, A.; Weber, B.; Collins, C.; Wasmuth, J. J.; Buetow, Kenneth; Murray, J. C.; Hayden, M. R.

In: Journal of Medical Genetics, Vol. 26, No. 11, 1989, p. 676-681.

Research output: Contribution to journalArticle

Ann, JT, Kanani, S, Shiang, R, Robbins, C, Quarrell, O, Huggins, M, Hedrick, A, Weber, B, Collins, C, Wasmuth, JJ, Buetow, K, Murray, JC & Hayden, MR 1989, 'Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene', Journal of Medical Genetics, vol. 26, no. 11, pp. 676-681. https://doi.org/10.1136/jmg.26.11.676
Ann, J. Theilm ; Kanani, S. ; Shiang, R. ; Robbins, C. ; Quarrell, O. ; Huggins, M. ; Hedrick, A. ; Weber, B. ; Collins, C. ; Wasmuth, J. J. ; Buetow, Kenneth ; Murray, J. C. ; Hayden, M. R. / Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene. In: Journal of Medical Genetics. 1989 ; Vol. 26, No. 11. pp. 676-681.
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