Non-occupational post exposure prophylaxis as a biobehavioral HIV-prevention intervention

S. Shoptaw, Erin Rotheram-Fuller, R. J. Landovitz, J. Wang, A. Moe, D. E. Kanouse, C. Reback

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

This project evaluated the feasibility and safety of a community-planned and financed program of non-occupational post exposure prophylaxis (nPEP) for 100 individuals. Individuals seeking nPEP within 72 hours of a potential HIV exposure were provided 28-day treatment using twice-daily lamivudine and zidovudine. Participants received a physical examination, HIV test and medications and were scheduled for follow-up counseling and data visits to 26-weeks. Results showed participants were highly educated (mean = 14.7 years), gay identified (63%), males (95%) who experienced an atypical, high-risk sexual event. Two participants tested HIV-positive at intake, who were previously unaware of their HIV status. The strongest demand (31% of cases) was on Mondays. The index event for the majority of cases (58%) involved unprotected anal sex, with 18% reporting condom failures. Only 15% tested positive for illicit drugs at initial visit. Of those dispensed the full 28 days of medication (n=84), 63 successfully completed the treatment course (75%). Retention dropped rapidly after the initial study visit, with only 49% completing a 26-week follow-up visit. No incident seroconversions were observed. That 75% of participants completed a full course of nPEP adds to the emerging evidence regarding nPEP feasibility. This project demonstrates the need for further research in the implementation of nPEP as a biobehavioral strategy for high-risk groups within a comprehensive HIV-prevention plan.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume20
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Post-Exposure Prophylaxis
prophylaxis
HIV
medication
Unsafe Sex
Lamivudine
Zidovudine
event
Condoms
Street Drugs
Sexual Behavior
Physical Examination
Counseling
counseling
incident
drug
Safety
examination
demand
Therapeutics

Keywords

  • AIDS
  • Feasibility
  • HIV
  • Non-occupational exposure
  • Post-exposure Prophylaxis
  • Prevention

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)
  • Social Sciences (miscellaneous)

Cite this

Non-occupational post exposure prophylaxis as a biobehavioral HIV-prevention intervention. / Shoptaw, S.; Rotheram-Fuller, Erin; Landovitz, R. J.; Wang, J.; Moe, A.; Kanouse, D. E.; Reback, C.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 20, No. 3, 03.2008, p. 376-381.

Research output: Contribution to journalArticle

Shoptaw, S. ; Rotheram-Fuller, Erin ; Landovitz, R. J. ; Wang, J. ; Moe, A. ; Kanouse, D. E. ; Reback, C. / Non-occupational post exposure prophylaxis as a biobehavioral HIV-prevention intervention. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. 2008 ; Vol. 20, No. 3. pp. 376-381.
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