Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Joshua A. Rabinowitz; John C. Lainson; Stephen Johnston; Chris Diehnelt

doi:10.1039/c7cc08242h

Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Joshua A. Rabinowitz, John C. Lainson, Stephen Johnston, Chris Diehnelt

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

Original language	English (US)
Pages (from-to)	1417-1420
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	12
DOIs	https://doi.org/10.1039/c7cc08242h
State	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c7cc08242h

Cite this

@article{ddf5c262d7b8436bb022c3e67918e252,

title = "Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands",

abstract = "We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.",

author = "Rabinowitz, {Joshua A.} and Lainson, {John C.} and Stephen Johnston and Chris Diehnelt",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c7cc08242h",

language = "English (US)",

volume = "54",

pages = "1417--1420",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

AU - Rabinowitz, Joshua A.

AU - Lainson, John C.

AU - Johnston, Stephen

AU - Diehnelt, Chris

PY - 2018

Y1 - 2018

N2 - We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

AB - We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

UR - http://www.scopus.com/inward/record.url?scp=85042014825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042014825&partnerID=8YFLogxK

U2 - 10.1039/c7cc08242h

DO - 10.1039/c7cc08242h

M3 - Article

C2 - 29297911

AN - SCOPUS:85042014825

SN - 1359-7345

VL - 54

SP - 1417

EP - 1420

JO - Chemical Communications

JF - Chemical Communications

IS - 12

ER -

Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this