Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Joshua A. Rabinowitz, John C. Lainson, Stephen Johnston, Chris Diehnelt

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

Original languageEnglish (US)
Pages (from-to)1417-1420
Number of pages4
JournalChemical Communications
Volume54
Issue number12
DOIs
StatePublished - Jan 1 2018

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Glycoproteins
Microarrays
Viruses
Peptides
Amino acids
Ligands
Amino Acids
Peptide Library
Antiviral Agents

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands. / Rabinowitz, Joshua A.; Lainson, John C.; Johnston, Stephen; Diehnelt, Chris.

In: Chemical Communications, Vol. 54, No. 12, 01.01.2018, p. 1417-1420.

Research output: Contribution to journalArticle

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