Non-adaptive origins of interactome complexity

Ariel Ferńndez, Michael Lynch

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The boundaries between prokaryotes, unicellular eukaryotes and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation. The resultant decline in the efficiency of selection seems to be sufficient to influence a wide range of attributes at the genomic level in a non-adaptive manner. A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of influencing phylogenetic diversity at the subcellular and cellular levels. Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways underlying long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relation between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for proteing-protein interactions that stabilize key gene functions. By this means, the complex protein architectures and interactions essential to the genesis of phenotypic diversity may initially emerge by non-adaptive mechanisms.

Original languageEnglish (US)
Pages (from-to)502-506
Number of pages5
JournalNature
Volume474
Issue number7352
DOIs
StatePublished - Jun 23 2011
Externally publishedYes

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Population Density
Genetic Drift
Eukaryota
Mutation
Protein Subunits
Proteins
Genes

ASJC Scopus subject areas

  • General

Cite this

Non-adaptive origins of interactome complexity. / Ferńndez, Ariel; Lynch, Michael.

In: Nature, Vol. 474, No. 7352, 23.06.2011, p. 502-506.

Research output: Contribution to journalArticle

Ferńndez, Ariel ; Lynch, Michael. / Non-adaptive origins of interactome complexity. In: Nature. 2011 ; Vol. 474, No. 7352. pp. 502-506.
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