Noise and fluctuations in nanowire biosensors

Gerhard Tulzer, Clemens Heitzinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

This work deals with the stochastic simulation of a nanowire biosensor surface and the surrounding liquid domain for DNA detection. The objective is an analysis of the fluctuations and of the biological noise induced by the inherent randomness of the hybridization process at the surface. We consider a coupled system of diffusion-reaction equations to model the movement of DNA oligomers as well as the hybridization processes at the functionalized surface of the sensor. Since analytical solutions cannot be derived, numerical investigation is necessary. Here, we present an algorithm different from the already published one in Tulzer and Heitzinger (2014) and show the non-monotonic behaviour of the variance in certain regimes. The variance determines the detection limit, which is an important quantity for optimal sensor design.

Original languageEnglish (US)
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
PublisherIFAC Secretariat
Pages761-765
Number of pages5
Volume48
Edition1
DOIs
StatePublished - Feb 1 2015
Event8th Vienna International Conference on Mathematical Modelling, MATHMOD 2015 - Vienna, Austria
Duration: Feb 18 2015Feb 20 2015

Other

Other8th Vienna International Conference on Mathematical Modelling, MATHMOD 2015
CountryAustria
CityVienna
Period2/18/152/20/15

Keywords

  • DNA hybridization
  • Nanowire biosensor
  • Stochastic processes.

ASJC Scopus subject areas

  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Noise and fluctuations in nanowire biosensors'. Together they form a unique fingerprint.

  • Cite this

    Tulzer, G., & Heitzinger, C. (2015). Noise and fluctuations in nanowire biosensors. In IFAC Proceedings Volumes (IFAC-PapersOnline) (1 ed., Vol. 48, pp. 761-765). IFAC Secretariat. https://doi.org/10.1016/j.ifacol.2015.05.079