No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial

Nataša Tasevska, Amanda J. Cross, Kevin W. Dodd, Regina G. Ziegler, Neil E. Caporaso, Rashmi Sinha

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Recent epidemiological studies have suggested that red and processed meat may increase the risk of lung cancer. Possible underlying mechanisms include mutagens produced during high-temperature cooking or preservation, or formed endogenously from heme iron in meat. We used data from 99,579 participants of both screened and nonscreened arms of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, aged 55-74 years, to investigate whether meat type, cooking method, doneness level, intake of specific meat mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8- trimethylimidazo[4,5-f]quinoxaline] (DiMeIQx), 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P)] and heme iron are associated with lung cancer. Participants' diet was assessed prospectively using a 124-item food frequency questionnaire and an additional meat-cooking module. Dietary data were used in conjunction with a database to estimate intake of MeIQx, DiMeIQx, PhIP, B(a)P and heme iron. After up to 8 years of follow-up, 782 incident lung cancer cases were ascertained. Lung cancer risk was not associated with the consumption of either red (men: HRQ 5 vs. Q1 = 1.11, 95% CI = 0.79-1.56, Ptrend = 0.42; women: HRQ5 vs. Q1 = 1.30, 95% CI = 0.87-1.95, Ptrend = 0.65) or processed meat (men: HRQ 5 vs. Q1 = 1.12, 95% CI = 0.83-1.53, Ptrend = 0.22; women: HRQ5 vs. Q1 = 0.98, 95% CI = 0.68-1.41, Ptrend = 0.32) in multivariable models. High-temperature cooking methods, level of meat doneness, meat mutagens and heme iron had no effect on lung cancer risk. In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk.

Original languageEnglish (US)
Pages (from-to)402-411
Number of pages10
JournalInternational Journal of Cancer
Volume128
Issue number2
DOIs
StatePublished - Jan 15 2011

Keywords

  • PLCO
  • diet
  • heme iron
  • lung cancer
  • meat
  • meat mutagens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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