TY - JOUR
T1 - No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial
AU - Tasevska, Nataša
AU - Cross, Amanda J.
AU - Dodd, Kevin W.
AU - Ziegler, Regina G.
AU - Caporaso, Neil E.
AU - Sinha, Rashmi
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Recent epidemiological studies have suggested that red and processed meat may increase the risk of lung cancer. Possible underlying mechanisms include mutagens produced during high-temperature cooking or preservation, or formed endogenously from heme iron in meat. We used data from 99,579 participants of both screened and nonscreened arms of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, aged 55-74 years, to investigate whether meat type, cooking method, doneness level, intake of specific meat mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8- trimethylimidazo[4,5-f]quinoxaline] (DiMeIQx), 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P)] and heme iron are associated with lung cancer. Participants' diet was assessed prospectively using a 124-item food frequency questionnaire and an additional meat-cooking module. Dietary data were used in conjunction with a database to estimate intake of MeIQx, DiMeIQx, PhIP, B(a)P and heme iron. After up to 8 years of follow-up, 782 incident lung cancer cases were ascertained. Lung cancer risk was not associated with the consumption of either red (men: HRQ 5 vs. Q1 = 1.11, 95% CI = 0.79-1.56, Ptrend = 0.42; women: HRQ5 vs. Q1 = 1.30, 95% CI = 0.87-1.95, Ptrend = 0.65) or processed meat (men: HRQ 5 vs. Q1 = 1.12, 95% CI = 0.83-1.53, Ptrend = 0.22; women: HRQ5 vs. Q1 = 0.98, 95% CI = 0.68-1.41, Ptrend = 0.32) in multivariable models. High-temperature cooking methods, level of meat doneness, meat mutagens and heme iron had no effect on lung cancer risk. In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk.
AB - Recent epidemiological studies have suggested that red and processed meat may increase the risk of lung cancer. Possible underlying mechanisms include mutagens produced during high-temperature cooking or preservation, or formed endogenously from heme iron in meat. We used data from 99,579 participants of both screened and nonscreened arms of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, aged 55-74 years, to investigate whether meat type, cooking method, doneness level, intake of specific meat mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8- trimethylimidazo[4,5-f]quinoxaline] (DiMeIQx), 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P)] and heme iron are associated with lung cancer. Participants' diet was assessed prospectively using a 124-item food frequency questionnaire and an additional meat-cooking module. Dietary data were used in conjunction with a database to estimate intake of MeIQx, DiMeIQx, PhIP, B(a)P and heme iron. After up to 8 years of follow-up, 782 incident lung cancer cases were ascertained. Lung cancer risk was not associated with the consumption of either red (men: HRQ 5 vs. Q1 = 1.11, 95% CI = 0.79-1.56, Ptrend = 0.42; women: HRQ5 vs. Q1 = 1.30, 95% CI = 0.87-1.95, Ptrend = 0.65) or processed meat (men: HRQ 5 vs. Q1 = 1.12, 95% CI = 0.83-1.53, Ptrend = 0.22; women: HRQ5 vs. Q1 = 0.98, 95% CI = 0.68-1.41, Ptrend = 0.32) in multivariable models. High-temperature cooking methods, level of meat doneness, meat mutagens and heme iron had no effect on lung cancer risk. In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk.
KW - PLCO
KW - diet
KW - heme iron
KW - lung cancer
KW - meat
KW - meat mutagens
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U2 - 10.1002/ijc.25327
DO - 10.1002/ijc.25327
M3 - Article
C2 - 20232386
AN - SCOPUS:78649571566
SN - 0020-7136
VL - 128
SP - 402
EP - 411
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -