NMDA receptor modulators in the treatment of drug addiction

Seven E. Tomek, Amber L. LaCrosse, Natali E. Nemirovsky, Michael Olive

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function.

Original languageEnglish (US)
Pages (from-to)251-268
Number of pages18
JournalPharmaceuticals
Volume6
Issue number2
DOIs
StatePublished - Feb 6 2013

Fingerprint

N-Methyl-D-Aspartate Receptors
Substance-Related Disorders
Drug Partial Agonism
Ligands
Implosive Therapy
Cycloserine
Memantine
Glutamate Receptors
Street Drugs
N-Methylaspartate
Cues
Glutamic Acid
Learning

Keywords

  • Antagonist
  • Glutamate
  • Glycine binding site
  • N-methyl-D-aspartate receptor
  • Partial agonist

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

NMDA receptor modulators in the treatment of drug addiction. / Tomek, Seven E.; LaCrosse, Amber L.; Nemirovsky, Natali E.; Olive, Michael.

In: Pharmaceuticals, Vol. 6, No. 2, 06.02.2013, p. 251-268.

Research output: Contribution to journalArticle

Tomek, SE, LaCrosse, AL, Nemirovsky, NE & Olive, M 2013, 'NMDA receptor modulators in the treatment of drug addiction', Pharmaceuticals, vol. 6, no. 2, pp. 251-268. https://doi.org/10.3390/ph6020251
Tomek, Seven E. ; LaCrosse, Amber L. ; Nemirovsky, Natali E. ; Olive, Michael. / NMDA receptor modulators in the treatment of drug addiction. In: Pharmaceuticals. 2013 ; Vol. 6, No. 2. pp. 251-268.
@article{72d69269752246669ffaecc982308042,
title = "NMDA receptor modulators in the treatment of drug addiction",
abstract = "Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function.",
keywords = "Antagonist, Glutamate, Glycine binding site, N-methyl-D-aspartate receptor, Partial agonist",
author = "Tomek, {Seven E.} and LaCrosse, {Amber L.} and Nemirovsky, {Natali E.} and Michael Olive",
year = "2013",
month = "2",
day = "6",
doi = "10.3390/ph6020251",
language = "English (US)",
volume = "6",
pages = "251--268",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - NMDA receptor modulators in the treatment of drug addiction

AU - Tomek, Seven E.

AU - LaCrosse, Amber L.

AU - Nemirovsky, Natali E.

AU - Olive, Michael

PY - 2013/2/6

Y1 - 2013/2/6

N2 - Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function.

AB - Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function.

KW - Antagonist

KW - Glutamate

KW - Glycine binding site

KW - N-methyl-D-aspartate receptor

KW - Partial agonist

UR - http://www.scopus.com/inward/record.url?scp=84873650190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873650190&partnerID=8YFLogxK

U2 - 10.3390/ph6020251

DO - 10.3390/ph6020251

M3 - Article

AN - SCOPUS:84873650190

VL - 6

SP - 251

EP - 268

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 2

ER -