Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD)

Elizabeth Watterson, Alexander Spitzer, Lucas R. Watterson, Ryan J. Brackney, Arturo R. Zavala, Michael Olive, Federico Sanabria

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Attention deficit hyperactivity disorder (ADHD) is associated with increased risk of tobacco dependence. Nicotine, the main psychoactive component of tobacco, appears to be implicated in ADHD-related tobacco dependence. However, the behavioral responsiveness to nicotine of the prevalent animal model of ADHD, the spontaneously hypertensive rat (SHR), is currently underinvestigated. The present study examined the activational effects of acute and chronic nicotine on the behavior of adult male SHRs, relative to Wistar Kyoto (WKY) controls. Experiment 1 verified baseline strain differences in open-field locomotor activity. Experiment 2 tested for baseline strain differences in rotational behavior using a Rotorat apparatus. Adult SHR and WKY rats were then exposed to a 7-day regimen of 0.6 mg/kg/d s.c. nicotine, or saline, prior to each assessment. A separate group of SHRs underwent similar training, but was pre-treated with mecamylamine, a cholinergic antagonist. Nicotine sensitization, context conditioning, and mecamylamine effects were then tested. Baseline strain differences were observed in open-field performance and in the number of full rotations in the Rotorat apparatus, but not in the number of 90° rotations or direction changes. In these latter measures, SHRs displayed weaker nicotine-induced rotational suppression than WKYs. Both strains expressed nicotine-induced sensitization of rotational activity, but evidence for strain differences in sensitization was ambiguous; context conditioning was not observed. Mecamylamine reversed the effects of nicotine on SHR performance. These findings are consistent with the hypothesis that a reduced aversion to nicotine (expressed in rats as robust locomotion) may facilitate smoking among adults with ADHD.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalBehavioural Brain Research
Volume312
DOIs
StatePublished - Oct 1 2016

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Attention Deficit Disorder with Hyperactivity
Nicotine
Mecamylamine
Inbred SHR Rats
Tobacco Use Disorder
Locomotion
Inbred WKY Rats
Cholinergic Antagonists
Tobacco
Animal Models
Smoking

Keywords

  • ADHD
  • Nicotine
  • Sensitization
  • Spontaneously hypertensive rat
  • Suppression
  • Wistar Kyoto

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD). / Watterson, Elizabeth; Spitzer, Alexander; Watterson, Lucas R.; Brackney, Ryan J.; Zavala, Arturo R.; Olive, Michael; Sanabria, Federico.

In: Behavioural Brain Research, Vol. 312, 01.10.2016, p. 333-340.

Research output: Contribution to journalArticle

Watterson, Elizabeth ; Spitzer, Alexander ; Watterson, Lucas R. ; Brackney, Ryan J. ; Zavala, Arturo R. ; Olive, Michael ; Sanabria, Federico. / Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD). In: Behavioural Brain Research. 2016 ; Vol. 312. pp. 333-340.
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