NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Jeffrey H. Kordower, Elliott J. Mufson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A role for impaired NGF mechanisms as an underlying component in the pathogenesis of Alzheimer's disease has yet to be realized. However, circumspect examination of the available data fails to provide sufficient evidence for rejecting this notion and further systematic evaluation along each step of NGF's mechanism of neurotrophic action is still required. This commentary argues that NGF may be involved in the degeneration observed in the basal forebrain in AD, or at the very least, plays a dynamic role in the disease process.

Original languageEnglish (US)
Pages (from-to)543-544
Number of pages2
JournalNeurobiology of Aging
Volume10
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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