Abstract
Bioassay-directed fractionation of a methyl ethyl ketone extract of the roots of Endlicheria aff resulted in the isolation of four new neolignans (1-4) and eight known compounds, namely, canellin A (5), canellin C (6), 3′-methoxyguianin (7), (7S,8R,1′S,5′S,6′R)- Δ2,8′′-3′,6′-dihydroxy-5′- methoxy-3,4-methylenedioxy-4′-oxo-8.1′,7.5′-neolignan (8), armenin-B (9), dillapiole (10), 1-allyl-2,6-dimethoxy-3,4-methylenedioxy-benzene (11), and ω-hydroxyisodillapiole (12). The structures of the new compounds (1-4) were established as (7S,8R,1′S,5′S,6′R)- Δ2′,8′-5′,6′-dihydroxy-3′- methoxy-3,4-methylenedioxy-4′-oxo-8.1′,7.5′-neolignan, (7S,8R,1′S,5′S,6′R)-Δ2′,8′- 3′,5′,6′-trihydroxy-3,4-methylenedioxy-4′-oxo-8. 1′,7.5′-neolignan, 2,4-dimethoxy-5,6-methylenedioxy-1-(2-propenyl) benzene, and 2,6-dimethoxy-3,4-methylenedioxycinnamyl alcohol, respectively, on the basis of spectroscopic interpretation.
Original language | English (US) |
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Pages (from-to) | 964-967 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry