New neolignans that inhibit DNA polymerase β lyase

V. S.Prakash Chaturvedula, Sidney M. Hecht, Zhijie Gao, Shannon H. Jones, Xizhi Feng, David G.I. Kingston

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Bioassay-directed fractionation of a methyl ethyl ketone extract of the roots of Endlicheria aff resulted in the isolation of four new neolignans (1-4) and eight known compounds, namely, canellin A (5), canellin C (6), 3′-methoxyguianin (7), (7S,8R,1′S,5′S,6′R)- Δ2,8′′-3′,6′-dihydroxy-5′- methoxy-3,4-methylenedioxy-4′-oxo-8.1′,7.5′-neolignan (8), armenin-B (9), dillapiole (10), 1-allyl-2,6-dimethoxy-3,4-methylenedioxy-benzene (11), and ω-hydroxyisodillapiole (12). The structures of the new compounds (1-4) were established as (7S,8R,1′S,5′S,6′R)- Δ2′,8′-5′,6′-dihydroxy-3′- methoxy-3,4-methylenedioxy-4′-oxo-8.1′,7.5′-neolignan, (7S,8R,1′S,5′S,6′R)-Δ2′,8′- 3′,5′,6′-trihydroxy-3,4-methylenedioxy-4′-oxo-8. 1′,7.5′-neolignan, 2,4-dimethoxy-5,6-methylenedioxy-1-(2-propenyl) benzene, and 2,6-dimethoxy-3,4-methylenedioxycinnamyl alcohol, respectively, on the basis of spectroscopic interpretation.

Original languageEnglish (US)
Pages (from-to)964-967
Number of pages4
JournalJournal of Natural Products
Volume67
Issue number6
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Chaturvedula, V. S. P., Hecht, S. M., Gao, Z., Jones, S. H., Feng, X., & Kingston, D. G. I. (2004). New neolignans that inhibit DNA polymerase β lyase. Journal of Natural Products, 67(6), 964-967. https://doi.org/10.1021/np030507y