New light on disordered ensembles: Ab initio structure determination of one particle from scattering fluctuations of many copies

D. K. Saldin, H. C. Poon, M. J. Bogan, S. Marchesini, D. A. Shapiro, Richard Kirian, Uwe Weierstall, John Spence

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We report on the first experimental ab initio reconstruction of an image of a single particle from fluctuations in the scattering from an ensemble of copies, randomly oriented about an axis. The method is applicable to identical particles frozen in space or time (as by snapshot diffraction from an x-ray free electron laser). These fluctuations enhance information obtainable from an experiment such as conventional small angle x-ray scattering.

Original languageEnglish (US)
Article number115501
JournalPhysical Review Letters
Issue number11
StatePublished - Mar 14 2011


ASJC Scopus subject areas

  • Physics and Astronomy(all)

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