New insights into extracellular and post-translational regulation of TGF-β family signalling pathways

Osamu Shimmi, Stuart Newfeld

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Members of the transforming growth factor-β (TGF-b) family of secreted proteins are present in all multicellular animals. TGF-b proteins are versatile intercellular signalling molecules that orchestrate cell fate decisions during development and maintain homeostasis in adults. The Smad family of signal transducers implements TGF-β signals in responsive cells. Given the ability of TGF-β ligands to induce dramatic responses in target cells, numerous regulatory mechanisms exist to prevent unintended consequences. Here we review new reports of extracellular and post-translational regulation in Drosophila and vertebrates. Extracellular topics include the regulation of TGF-β signalling range and the coordination between tissue morphogenesis and TGF-β signalling. Post-translational topics include the regulation of TGF-β signal transduction by Gsk3-β phosphorylation of Smads and by cycles of Smad mono-and deubiquitylation. Extension of the ubiquitylation data to the Hippo pathway is also discussed.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalJournal of Biochemistry
Volume154
Issue number1
DOIs
StatePublished - Jul 2013

Keywords

  • BMP
  • Smad
  • facilitated transport
  • phosphorylation
  • ubiquitylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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