New Hyperforin Derivatives from Hypericum revolutum VAHL with Growth‐Inhibitory Activity against a Human Colon Carcinoma Cell Line

Laurent A. Decosterd, Helen Stoeckli‐Evans, Jean Chapuis, Jerome D. onthi, Bernard Sordat, Kurt Hostettmann

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The crude petroleum‐ether extract of the root bark of Hypericum revolutum VAHL (Guttiferae) exhibited in vitro growth‐inhibitory activity against the Co‐115 human colon carcinoma cell line. Activity‐guided fractionation of this extract resulted in the isolation of two new hyperforin derivatives 1 and 2. The structure of 1 (hyperevolutin A) was established by X‐ray analysis as the 4‐hydroxy‐8‐exo‐methyl‐5,7‐exo‐bis(3‐methylbut‐2‐enyl)‐1‐(2‐methyl‐1‐oxopropyl)‐8‐endo‐(4‐methylpent‐3‐enyl)bicyclo[3.3.1]non‐3‐ene‐2,9‐dione. The structure of the homologue 2 was deduced by comparison of its UV and 1H‐ and 13C‐NMR spectra with those of 1.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
JournalHelvetica Chimica Acta
Volume72
Issue number3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Hypericum
Fractionation
Complex Mixtures
cultured cells
fractionation
isolation
Colon
cancer
Cells
X-Rays
Derivatives
Carcinoma
Cell Line
In Vitro Techniques
hyperforin

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

New Hyperforin Derivatives from Hypericum revolutum VAHL with Growth‐Inhibitory Activity against a Human Colon Carcinoma Cell Line. / Decosterd, Laurent A.; Stoeckli‐Evans, Helen; Chapuis, Jean; onthi, Jerome D.; Sordat, Bernard; Hostettmann, Kurt.

In: Helvetica Chimica Acta, Vol. 72, No. 3, 01.01.1989, p. 464-471.

Research output: Contribution to journalArticle

Decosterd, Laurent A. ; Stoeckli‐Evans, Helen ; Chapuis, Jean ; onthi, Jerome D. ; Sordat, Bernard ; Hostettmann, Kurt. / New Hyperforin Derivatives from Hypericum revolutum VAHL with Growth‐Inhibitory Activity against a Human Colon Carcinoma Cell Line. In: Helvetica Chimica Acta. 1989 ; Vol. 72, No. 3. pp. 464-471.
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