TY - JOUR
T1 - New Hyperforin Derivatives from Hypericum revolutum VAHL with Growth‐Inhibitory Activity against a Human Colon Carcinoma Cell Line
AU - Decosterd, Laurent A.
AU - Stoeckli‐Evans, Helen
AU - Chapuis, Jean‐Charles ‐C
AU - onthi, Jerome D.
AU - Sordat, Bernard
AU - Hostettmann, Kurt
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/5/3
Y1 - 1989/5/3
N2 - The crude petroleum‐ether extract of the root bark of Hypericum revolutum VAHL (Guttiferae) exhibited in vitro growth‐inhibitory activity against the Co‐115 human colon carcinoma cell line. Activity‐guided fractionation of this extract resulted in the isolation of two new hyperforin derivatives 1 and 2. The structure of 1 (hyperevolutin A) was established by X‐ray analysis as the 4‐hydroxy‐8‐exo‐methyl‐5,7‐exo‐bis(3‐methylbut‐2‐enyl)‐1‐(2‐methyl‐1‐oxopropyl)‐8‐endo‐(4‐methylpent‐3‐enyl)bicyclo[3.3.1]non‐3‐ene‐2,9‐dione. The structure of the homologue 2 was deduced by comparison of its UV and 1H‐ and 13C‐NMR spectra with those of 1.
AB - The crude petroleum‐ether extract of the root bark of Hypericum revolutum VAHL (Guttiferae) exhibited in vitro growth‐inhibitory activity against the Co‐115 human colon carcinoma cell line. Activity‐guided fractionation of this extract resulted in the isolation of two new hyperforin derivatives 1 and 2. The structure of 1 (hyperevolutin A) was established by X‐ray analysis as the 4‐hydroxy‐8‐exo‐methyl‐5,7‐exo‐bis(3‐methylbut‐2‐enyl)‐1‐(2‐methyl‐1‐oxopropyl)‐8‐endo‐(4‐methylpent‐3‐enyl)bicyclo[3.3.1]non‐3‐ene‐2,9‐dione. The structure of the homologue 2 was deduced by comparison of its UV and 1H‐ and 13C‐NMR spectra with those of 1.
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U2 - 10.1002/hlca.19890720307
DO - 10.1002/hlca.19890720307
M3 - Article
AN - SCOPUS:0024520569
SN - 0018-019X
VL - 72
SP - 464
EP - 471
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 3
ER -