New Hyperforin Derivatives from Hypericum revolutum VAHL with Growth‐Inhibitory Activity against a Human Colon Carcinoma Cell Line

Laurent A. Decosterd, Helen Stoeckli‐Evans, Jean‐Charles ‐C Chapuis, Jerome D. onthi, Bernard Sordat, Kurt Hostettmann

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The crude petroleum‐ether extract of the root bark of Hypericum revolutum VAHL (Guttiferae) exhibited in vitro growth‐inhibitory activity against the Co‐115 human colon carcinoma cell line. Activity‐guided fractionation of this extract resulted in the isolation of two new hyperforin derivatives 1 and 2. The structure of 1 (hyperevolutin A) was established by X‐ray analysis as the 4‐hydroxy‐8‐exo‐methyl‐5,7‐exo‐bis(3‐methylbut‐2‐enyl)‐1‐(2‐methyl‐1‐oxopropyl)‐8‐endo‐(4‐methylpent‐3‐enyl)bicyclo[3.3.1]non‐3‐ene‐2,9‐dione. The structure of the homologue 2 was deduced by comparison of its UV and 1H‐ and 13C‐NMR spectra with those of 1.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
JournalHelvetica Chimica Acta
Volume72
Issue number3
DOIs
StatePublished - May 3 1989

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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