TY - JOUR
T1 - New cytotoxic principles from Datisca glomerata
AU - Sasamori, Hiroshi
AU - Reddy, K. Sambi
AU - Kirkup, Michael P.
AU - Shabanowitz, Jeffrey
AU - Lynn, David G.
AU - Hecht, Sidney M.
AU - Woode, Kwamena A.
AU - Bryan, Robert F.
AU - Campbell, James
AU - Lynn, William S.
AU - Egert, Ernst
AU - Sheldrick, George M.
PY - 1983
Y1 - 1983
N2 - Datisca glomerata has been systematically fractionated by following cellular toxicity in an effort to identify previously uncharacterized cytotoxic principles. Several new cucurbitacin glycosides, including datiscosides B(8), C(3), D(9), E(4), F(5), G(6), and H(10) and the known compound datiscoside (1), as well as cucurbitacins B(11), D(2), and F(7) have been isolated and characterized. Structures were assigned to the compounds on the basis of their high field 1H n.m.r., 13C n.m.r., high-resolution mass spectra (Cl, El, and FD) and chemical interconversions. The structure of datiscoside C(3) was independently established by single-crystal X-ray analysis at 193 and 293 K.
AB - Datisca glomerata has been systematically fractionated by following cellular toxicity in an effort to identify previously uncharacterized cytotoxic principles. Several new cucurbitacin glycosides, including datiscosides B(8), C(3), D(9), E(4), F(5), G(6), and H(10) and the known compound datiscoside (1), as well as cucurbitacins B(11), D(2), and F(7) have been isolated and characterized. Structures were assigned to the compounds on the basis of their high field 1H n.m.r., 13C n.m.r., high-resolution mass spectra (Cl, El, and FD) and chemical interconversions. The structure of datiscoside C(3) was independently established by single-crystal X-ray analysis at 193 and 293 K.
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U2 - 10.1039/p19830001333
DO - 10.1039/p19830001333
M3 - Article
AN - SCOPUS:37049111347
SN - 1472-7781
SP - 1333
EP - 1347
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
ER -