Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

Paul D. Coleman, Dorothy G. Flood

Research output: Contribution to journalReview article

625 Scopus citations

Abstract

Factors which limit the interpretation of studies of aging brain include: secular trends, species and strain differences, effects of tissue processing, and bias which may be introduced at many levels of an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers and dendritic extent in normally aging rodent, monkey and human brain and in Alzheimer's disease. It is concluded that neuron loss and change in dendritic extent in normal aging are regionally specific, and that corresponding brain regions do not always change in similar ways in rodents and primates. It is suggested that such differences may, in part, be due to inconsistent definitions of 'aged' among species. In Alzheimer's disease there is excess neuron loss and dendritic regression in some, but not all, brain regions. Measures of the morphological substrates of brain function show appreciable overlap between AD and control groups. It is hypothesized that the static, post-mortem status of brain morphology may not adequately reflect the functional capabilities of the dynamic morphology of the living brain.

Original languageEnglish (US)
Pages (from-to)521-545
Number of pages25
JournalNeurobiology of Aging
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Keywords

  • Central nervous system
  • Dendrites
  • Dendritic spines
  • Gerontology
  • Human Alzheimer's disease
  • Neuron numbers
  • Primate
  • Review
  • Rodent

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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