Neuromuscular electrical stimulation induced forelimb movement in a rodent model

Tsukasa Kanchiku, James V. Lynskey, Danielle Protas, James Abbas, Ranu Jung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Upper extremity neuromuscular electrical stimulation (FNS) has long been utilized as a neuroprosthesis to restore hand-grasp function in individuals with neurological disorders and injuries. More recently, electrical stimulation is being used as a rehabilitative therapy to tap into central nervous system plasticity. Here, we present initial development of a rodent model for neuromuscular stimulation induced forelimb movement that can be used as a platform to investigate stimulation-induced plasticity. The motor points for flexors and extensors of the shoulder, elbow, and digits were identified and implanted with custom-built stimulation electrodes. The strength-duration curves were determined and from these curves the appropriate stimulation parameters required to produce consistent isolated contraction of each muscle with adequate joint movement were determined. Using these parameters and previous locomotor EMG data, stimulation was performed on each joint muscle pair to produce reciprocal flexion/extension movements in the shoulder, elbow, and digits, while 3D joint kinematics were assessed. Additionally, co-stimulation of multiple muscles across multiple forelimb joints was performed to produce stable multi-joint movements similar to those observed during reach-grasp-release movements. Future work will utilize this model to investigate the efficacy and underlying mechanisms of forelimb neuromuscular stimulation therapy to promote recovery and plasticity after neural injury in rodents.

Original languageEnglish (US)
Pages (from-to)317-326
Number of pages10
JournalJournal of Neuroscience Methods
Volume167
Issue number2
DOIs
StatePublished - Jan 30 2008

Fingerprint

Forelimb
Electric Stimulation
Rodentia
Joints
Hand Strength
Elbow
Muscles
Neuronal Plasticity
Wounds and Injuries
Muscle Contraction
Nervous System Diseases
Biomechanical Phenomena
Upper Extremity
Electrodes
Central Nervous System
Hand
Therapeutics

Keywords

  • Forelimb
  • Grasp
  • Kinematics
  • Neuromuscular electrical stimulation
  • Reach
  • Rodent

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuromuscular electrical stimulation induced forelimb movement in a rodent model. / Kanchiku, Tsukasa; Lynskey, James V.; Protas, Danielle; Abbas, James; Jung, Ranu.

In: Journal of Neuroscience Methods, Vol. 167, No. 2, 30.01.2008, p. 317-326.

Research output: Contribution to journalArticle

Kanchiku, Tsukasa ; Lynskey, James V. ; Protas, Danielle ; Abbas, James ; Jung, Ranu. / Neuromuscular electrical stimulation induced forelimb movement in a rodent model. In: Journal of Neuroscience Methods. 2008 ; Vol. 167, No. 2. pp. 317-326.
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