Neural repair strategies for Parkinson's disease: Insights from primate models

Katherine Soderstrom, Jennifer O'Malley, Kathy Steece-Collier, Jeffrey H. Kordower

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment. In this review, we attempt to give a brief overview of the animal models of PD currently used, with a more comprehensive focus on the advantages and disadvantages presented by their use in the nonhuman primate. In particular, discussion addresses the 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydopyridine (MPTP), rotenone, paraquat, and maneb parkinsonian models. Additionally, the role of primate PD models in the development of novel therapies, such as trophic factor delivery, grafting, and deep brain stimulation, are described. Finally, the contribution of primate PD models to our understanding of the etiology and pathology of human PD is discussed.

Original languageEnglish (US)
Pages (from-to)251-265
Number of pages15
JournalCell Transplantation
Volume15
Issue number3
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Animal models
  • Nonhuman primates
  • Parkinson's disease
  • Therapeutics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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