Neural processing critical for distinguishing between speech sounds

K. Kim, Luke Adams, Lynsey M. Keator, Shannon M. Sheppard, Bonnie L. Breining, C. Rorden, Julius Fridriksson, Leonardo Bonilha, Corianne Rogalsky, T. Love, Gregory Hickok, Argye E. Hillis

Research output: Contribution to journalArticle

Abstract

We aimed to identify neural regions where ischemia acutely after stroke is associated with impairment in phoneme discrimination, and to determine whether such deficits are associated with impairment of spoken word comprehension. We evaluated 33 patients within 48 h of left hemisphere ischemic stroke onset with tests of phoneme discrimination and word-picture matching. We identified Pearson correlations between accuracy in phoneme discrimination and accuracy of word comprehension and identified areas where the percentage of infarcted tissue was associated with severity of phoneme discrimination deficit. We found that 54% had deficits in phoneme discrimination relative to healthy controls. Accuracy in phoneme discrimination correlated with accuracy on word comprehension tests. Damage to left intraparietal sulcus and hypoperfusion and/or infarct of left superior temporal gyrus were associated with phoneme discrimination deficits acutely, although patients with these lesions showed improvement or resolution of the deficit by six months.

Original languageEnglish (US)
Article number104677
JournalBrain and Language
Volume197
DOIs
StatePublished - Oct 2019

Keywords

  • Acute ischemic stroke
  • Auditory processing
  • Lesion-deficit mapping
  • Phoneme discrimination

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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    Kim, K., Adams, L., Keator, L. M., Sheppard, S. M., Breining, B. L., Rorden, C., Fridriksson, J., Bonilha, L., Rogalsky, C., Love, T., Hickok, G., & Hillis, A. E. (2019). Neural processing critical for distinguishing between speech sounds. Brain and Language, 197, [104677]. https://doi.org/10.1016/j.bandl.2019.104677