Neural processing critical for distinguishing between speech sounds

K. Kim, Luke Adams, Lynsey M. Keator, Shannon M. Sheppard, Bonnie L. Breining, C. Rorden, Julius Fridriksson, Leonardo Bonilha, Corianne Reddy, T. Love, Gregory Hickok, Argye E. Hillis

Research output: Contribution to journalArticle

Abstract

We aimed to identify neural regions where ischemia acutely after stroke is associated with impairment in phoneme discrimination, and to determine whether such deficits are associated with impairment of spoken word comprehension. We evaluated 33 patients within 48 h of left hemisphere ischemic stroke onset with tests of phoneme discrimination and word-picture matching. We identified Pearson correlations between accuracy in phoneme discrimination and accuracy of word comprehension and identified areas where the percentage of infarcted tissue was associated with severity of phoneme discrimination deficit. We found that 54% had deficits in phoneme discrimination relative to healthy controls. Accuracy in phoneme discrimination correlated with accuracy on word comprehension tests. Damage to left intraparietal sulcus and hypoperfusion and/or infarct of left superior temporal gyrus were associated with phoneme discrimination deficits acutely, although patients with these lesions showed improvement or resolution of the deficit by six months.

Original languageEnglish (US)
Article number104677
JournalBrain and Language
Volume197
DOIs
StatePublished - Oct 1 2019

Fingerprint

Phonetics
discrimination
deficit
comprehension
stroke
Stroke
Parietal Lobe
Temporal Lobe
Discrimination (Psychology)
Discrimination
Phoneme
Speech Sounds
damages
Ischemia

Keywords

  • Acute ischemic stroke
  • Auditory processing
  • Lesion-deficit mapping
  • Phoneme discrimination

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Kim, K., Adams, L., Keator, L. M., Sheppard, S. M., Breining, B. L., Rorden, C., ... Hillis, A. E. (2019). Neural processing critical for distinguishing between speech sounds. Brain and Language, 197, [104677]. https://doi.org/10.1016/j.bandl.2019.104677

Neural processing critical for distinguishing between speech sounds. / Kim, K.; Adams, Luke; Keator, Lynsey M.; Sheppard, Shannon M.; Breining, Bonnie L.; Rorden, C.; Fridriksson, Julius; Bonilha, Leonardo; Reddy, Corianne; Love, T.; Hickok, Gregory; Hillis, Argye E.

In: Brain and Language, Vol. 197, 104677, 01.10.2019.

Research output: Contribution to journalArticle

Kim, K, Adams, L, Keator, LM, Sheppard, SM, Breining, BL, Rorden, C, Fridriksson, J, Bonilha, L, Reddy, C, Love, T, Hickok, G & Hillis, AE 2019, 'Neural processing critical for distinguishing between speech sounds', Brain and Language, vol. 197, 104677. https://doi.org/10.1016/j.bandl.2019.104677
Kim K, Adams L, Keator LM, Sheppard SM, Breining BL, Rorden C et al. Neural processing critical for distinguishing between speech sounds. Brain and Language. 2019 Oct 1;197. 104677. https://doi.org/10.1016/j.bandl.2019.104677
Kim, K. ; Adams, Luke ; Keator, Lynsey M. ; Sheppard, Shannon M. ; Breining, Bonnie L. ; Rorden, C. ; Fridriksson, Julius ; Bonilha, Leonardo ; Reddy, Corianne ; Love, T. ; Hickok, Gregory ; Hillis, Argye E. / Neural processing critical for distinguishing between speech sounds. In: Brain and Language. 2019 ; Vol. 197.
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