Neandertal DNA sequences and the origin of modern humans

Matthias Krings, Anne Stone, Ralf W. Schmitz, Heike Krainitzki, Mark Stoneking, Svante Pääbo

Research output: Contribution to journalArticle

838 Citations (Scopus)

Abstract

DNA was extracted from file Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandertal sequence falls outside the variation of modern humans. Furthermore, the age of the common ancestor of the Neandertal and modem human mtDNAs is estimated to be four times greater than that of the common ancestor of human mtDNAs. This suggests that Neandertals went extinct without contributing mtDNA to modern humans.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalCell
Volume90
Issue number1
DOIs
StatePublished - Jul 11 1997
Externally publishedYes

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Neanderthals
DNA sequences
Mitochondrial DNA
Modems
Fossils
DNA
Germany
Clone Cells
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Krings, M., Stone, A., Schmitz, R. W., Krainitzki, H., Stoneking, M., & Pääbo, S. (1997). Neandertal DNA sequences and the origin of modern humans. Cell, 90(1), 19-30. https://doi.org/10.1016/S0092-8674(00)80310-4

Neandertal DNA sequences and the origin of modern humans. / Krings, Matthias; Stone, Anne; Schmitz, Ralf W.; Krainitzki, Heike; Stoneking, Mark; Pääbo, Svante.

In: Cell, Vol. 90, No. 1, 11.07.1997, p. 19-30.

Research output: Contribution to journalArticle

Krings, M, Stone, A, Schmitz, RW, Krainitzki, H, Stoneking, M & Pääbo, S 1997, 'Neandertal DNA sequences and the origin of modern humans', Cell, vol. 90, no. 1, pp. 19-30. https://doi.org/10.1016/S0092-8674(00)80310-4
Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S. Neandertal DNA sequences and the origin of modern humans. Cell. 1997 Jul 11;90(1):19-30. https://doi.org/10.1016/S0092-8674(00)80310-4
Krings, Matthias ; Stone, Anne ; Schmitz, Ralf W. ; Krainitzki, Heike ; Stoneking, Mark ; Pääbo, Svante. / Neandertal DNA sequences and the origin of modern humans. In: Cell. 1997 ; Vol. 90, No. 1. pp. 19-30.
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