Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

David E. Berry, Laurie MacKenzie, Elva A. Shultis, James A. Chan, Sidney M. Hecht

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalJournal of Organic Chemistry
Volume57
Issue number2
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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