Naturally occurring inhibitors of topoisomerase I mediated DNA relaxation

David E. Berry, Laurie MacKenzie, Elva A. Shultis, James A. Chan, Sidney Hecht

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalJournal of Organic Chemistry
Volume57
Issue number2
StatePublished - 1992
Externally publishedYes

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Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Bioassay
DNA
Fractionation
Methanol
corilagin
chebulagic acid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Berry, D. E., MacKenzie, L., Shultis, E. A., Chan, J. A., & Hecht, S. (1992). Naturally occurring inhibitors of topoisomerase I mediated DNA relaxation. Journal of Organic Chemistry, 57(2), 420-422.

Naturally occurring inhibitors of topoisomerase I mediated DNA relaxation. / Berry, David E.; MacKenzie, Laurie; Shultis, Elva A.; Chan, James A.; Hecht, Sidney.

In: Journal of Organic Chemistry, Vol. 57, No. 2, 1992, p. 420-422.

Research output: Contribution to journalArticle

Berry, DE, MacKenzie, L, Shultis, EA, Chan, JA & Hecht, S 1992, 'Naturally occurring inhibitors of topoisomerase I mediated DNA relaxation', Journal of Organic Chemistry, vol. 57, no. 2, pp. 420-422.
Berry, David E. ; MacKenzie, Laurie ; Shultis, Elva A. ; Chan, James A. ; Hecht, Sidney. / Naturally occurring inhibitors of topoisomerase I mediated DNA relaxation. In: Journal of Organic Chemistry. 1992 ; Vol. 57, No. 2. pp. 420-422.
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