Nanotechnology applications of nucleic acid programmable protein arrays

Claudio Nicolini, Joshua LaBaer

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

NAPPA slides printed using the four genes JUN, P53, CDK2 and CDK4, were analyzed by means of fluorescence labeling in conjunction with DNASER and Bioinformatics and by means of several innovative Label Free approaches based on Atomic Force Microscopy (AFM), Nanogravimetry, Mass Spectrometry (MS) and Anodic Porous Alumina (APA), strictly using all technologies being developed in house. The experimental activities part of this Volume and summarized in this review, are proved capable to underline and assess the feasibility of Nucleic Acid Programmable Protein Arrays (NAPPA) and of its Label Free approaches, as well the traditional fluorescence technique utilizing the DNASER, in contributing to the progress of functional proteomics towards the understanding of the molecular events controlling cell cycle and cell transformation.

Original languageEnglish (US)
Title of host publicationFunctional Proteomics and Nanotechnology-Based Microarrays
PublisherPan Stanford Publishing Pte. Ltd.
Pages1-29
Number of pages29
ISBN (Print)9789814267762
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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