TY - JOUR
T1 - Nanoscale inorganic scaffolds as therapeutics and delivery vehicles
AU - Urie, Russell
AU - Rege, Kaushal
N1 - Funding Information:
The authors thank the National Institute of General Medical Sciences, NIH (Grant 1R01GM093229-01A1 ) and the Mayo Center for Regenerative Medicine for funding. The authors sincerely apologize to the numerous researchers whose works were not included in this article due to space constraints.
Publisher Copyright:
© 2015 Published by Elsevier Ltd.
PY - 2015/2
Y1 - 2015/2
N2 - Effective vehicles are often required to deliver nucleic acids and drugs to diseased tissues due to poor stability, susceptibility to enzymatic degradation, and/or unfavorable pharmacokinetics associated with these therapeutic molecules. Nanostructures can be employed to load, target, and release nucleic acid and drug therapeutics selectively to pre-determined sites in the body. Following the widespread use and success of organic nanoparticles, inorganic nanoparticles are being increasingly investigated as therapeutics and as vehicles in nucleic acid and drug delivery. Inorganic nanoparticles demonstrate unique physicochemical properties not associated with their organic counterparts. In addition, ease of synthesis and surface modification, tenability of size and shape, and multifunctionality associated with inorganic nanoparticles make them attractive platforms for biomedical applications. This review discusses recent developments in gold nanoparticles, carbon nanotubes, graphene oxide nanoparticles, iron oxide nanoparticles, calcium phosphate nanoparticles, and mesoporous silica nanoparticles as therapeutics and delivery vehicles, with a focus on applications in cancer diseases.
AB - Effective vehicles are often required to deliver nucleic acids and drugs to diseased tissues due to poor stability, susceptibility to enzymatic degradation, and/or unfavorable pharmacokinetics associated with these therapeutic molecules. Nanostructures can be employed to load, target, and release nucleic acid and drug therapeutics selectively to pre-determined sites in the body. Following the widespread use and success of organic nanoparticles, inorganic nanoparticles are being increasingly investigated as therapeutics and as vehicles in nucleic acid and drug delivery. Inorganic nanoparticles demonstrate unique physicochemical properties not associated with their organic counterparts. In addition, ease of synthesis and surface modification, tenability of size and shape, and multifunctionality associated with inorganic nanoparticles make them attractive platforms for biomedical applications. This review discusses recent developments in gold nanoparticles, carbon nanotubes, graphene oxide nanoparticles, iron oxide nanoparticles, calcium phosphate nanoparticles, and mesoporous silica nanoparticles as therapeutics and delivery vehicles, with a focus on applications in cancer diseases.
UR - http://www.scopus.com/inward/record.url?scp=84923322652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923322652&partnerID=8YFLogxK
U2 - 10.1016/j.coche.2014.12.004
DO - 10.1016/j.coche.2014.12.004
M3 - Review article
AN - SCOPUS:84923322652
VL - 7
SP - 120
EP - 128
JO - Current Opinion in Chemical Engineering
JF - Current Opinion in Chemical Engineering
SN - 2211-3398
ER -
