Abstract

A nanopore protein biosensor using a copolymer and diffusive flow of the test sample was developed. The copolymer coated within the nanopore can capture the antibody, which then captures the antigen. Diffusive flow of a test sample can be obtained using a concentration gradient between the nanopore and the micropore sides. No applied voltage was used to create the electrokinetic flow of the test liquid. The present nanopore protein biosensor showed high sensitivity and detected antigen quantities as low as 0.15 nM (4 pg/mL).

Original languageEnglish (US)
Article number127002
JournalJapanese Journal of Applied Physics
Volume50
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Nanopores
bioinstrumentation
Biosensors
antigens
proteins
Proteins
copolymers
Antigens
Copolymers
electrokinetics
antibodies
Antibodies
gradients
sensitivity
electric potential
liquids
Liquids
Electric potential

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Nanopore protein biosensor using diffusive flow. / Jung, Jung Yeul; Thornton, Trevor; Chiari, Marcella; Kim, Tae Hyoung.

In: Japanese Journal of Applied Physics, Vol. 50, No. 12, 127002, 12.2011.

Research output: Contribution to journalArticle

Jung, Jung Yeul ; Thornton, Trevor ; Chiari, Marcella ; Kim, Tae Hyoung. / Nanopore protein biosensor using diffusive flow. In: Japanese Journal of Applied Physics. 2011 ; Vol. 50, No. 12.
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