Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury

Vimala N. Bharadwaj, Connor Copeland, Trent R. Anderson, Jonathan Lifshitz, Vikram Kodibagkar, Sarah Stabenfeldt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoparticle (NP)-based systems have recently gained significant traction and NP applications for brain disorders, specifically traumatic brain injuries (TBI) are limited by the complex pathology including blood-brain barrier (BBB) disruption. Previously, we have established in both focal and diffuse injury models of TBI that 20-500 nm NPs accumulate within the injury region out to 24h post-injury correlating with BBB disruption 1,2 . Seminal TBI studies in male rodents suggest a biphasic BBB opening with the first peak at acute (~3-6h) time point followed by a delayed opening (~3d) after TBI 3,4 . Therefore, the first objective of this study aimed to characterize extended NP delivery outside of 24hr post-injury. Secondly, sex is known to play a role in the morbidity and mortality after TBI, yet the underlying mechanisms are not well elucidated. Early sex-specific studies reported decrease BBB disruption in female rodents compared to the males within the first 6h following injury 5,6 . However, sex differences in BBB disruption beyond this 6h time point after TBI has not been studied. Therefore, our second objective was to assess potential sex-dependent differences in BBB disruption and subsequent NP accumulation following TBI. Ultimately, we revealed key sex-dependent considerations for NP delivery strategies following TBI.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Blood-Brain Barrier
Nanoparticles
Brain Injuries
Brain
Wounds and Injuries
Sex Characteristics
Rodentia
Traumatic Brain Injury
Traction
Brain Diseases
Pathology
Morbidity
Mortality

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Bharadwaj, V. N., Copeland, C., Anderson, T. R., Lifshitz, J., Kodibagkar, V., & Stabenfeldt, S. (2019). Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury. / Bharadwaj, Vimala N.; Copeland, Connor; Anderson, Trent R.; Lifshitz, Jonathan; Kodibagkar, Vikram; Stabenfeldt, Sarah.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bharadwaj, VN, Copeland, C, Anderson, TR, Lifshitz, J, Kodibagkar, V & Stabenfeldt, S 2019, Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Bharadwaj VN, Copeland C, Anderson TR, Lifshitz J, Kodibagkar V, Stabenfeldt S. Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Bharadwaj, Vimala N. ; Copeland, Connor ; Anderson, Trent R. ; Lifshitz, Jonathan ; Kodibagkar, Vikram ; Stabenfeldt, Sarah. / Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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